氨茶碱联合小剂量盐酸异丙嗪治疗喘息型慢性支气管炎疗效观察

Efficacy observation of aminophylline joint small dose of promethazine hydrochloride in treatment of chronic asthmatic bronchitis

目的探讨氨茶碱联合小剂量盐酸异丙嗪治疗喘息型慢性支气管炎的临床疗效。方法选取2008年6月～2011年6月本院收治的喘息型慢性支气管炎患者72例,将其随机分为观察组和对照组各36例,对照组采用氨茶碱治疗,观察组在对照组治疗的基础上加用小剂量盐酸异丙嗪,7d为1个疗程。疗程结束后比较两组的临床治疗效果,分析治疗前后动脉血氧分压(PaO2)、动脉二氧化碳分压(PaCO2)及1s用力呼气容积(FEV1)的变化。结果疗程结束后观察组总有效率为91.67%,显著高于对照组的75.00%,两组差异有统计学意义(χ2=10.63,P<0.05)。治疗后两组PaO2、PaCO2及FEV1均较治疗前改善(P<0.05),且观察组改善较对照组明显,两组间差异有统计学意义(P<0.05)。结论氨茶碱联合小剂量盐酸异丙嗪治疗喘息型慢性支气管炎,疗效显著,值得临床推广应用。

Objective To investigate the clinical efficacy of aminophylline combined with low dose of promethazine hy drochloride in the treatment of chronic asthmatic bronchitis.Methods Seventy-two cases of patients with chronic asthmatic bronchitis in our hospital from June 2008 to June 2011 were randomly divided into observation group and control group,36 cases in each group,the control group were treated with aminophylline,the observation group were given small dose of promethazine hydrochloride on the basis of the control group,seven days for a course.Clinical outcomes after treatment were compared,arterial oxygen tension （PaO 2）,changes in arterial carbon dioxide partial pressure （PaCO 2） and one second forced expiratory volume （FEV1） before and after treatment were analyzed.Results The total effective rate of the observation group after treatment was 91.67%,which was significantly higher than 75.00% of the control group,the difference be tween the two groups was statistically significant （χ 2=10.63,P 0.05）.After treatment,the PaO 2,PaCO 2 and FEV1 were all improved compared with before treatment （P 0.05）,and the observation group improved better than that of the control group,the difference between the two groups was statistically significant （P 0.05）.Conclusion The treatment of chronic asthmatic bronchitis of aminophylline in combination with low dose of promethazine hydrochloride is effective,and be wor thy of clinical application.