648例药品不良反应回顾性分析

Retrospective analysis on 648 cases of ADRs Reports

目的了解本院药品不良反应的规律和特点,为临床用药提供参考。方法对本院2007～2011年上报的648例药品不良反应报告进行回顾性分析。结果在648例ADR报告中,78例(12.04%)为严重的ADR,158例(24.38%)为新发ADR;医护人员是ADR报告的主体;发生ADR者以青壮年及老年患者居多;静脉给药、抗感染药更易发生ADR;ADR主要累及皮肤及其附件、消化及循环系统。结论临床应重视ADR的监测和报告工作,且应加强抗菌药物应用管理,尽量减少和避免ADR的发生。

Objective To understand the characteristics and laws of ADR in our hospital and make the result as a refer ence for the clinic.Methods Six hundred and forty-eight cases of ADR reported in our hospital from 2007 to 2011 were retrospectively analyzed.Results Among 648 cases of ADR reports,78 cases （12.04%） were severe,158 cases （24.38%） were new;Medical personnel was the main body of ADR report;Happen to prime the ADR and elderly patients were in the majority;Intravenous drug,fight infection occurred more medicine ADR;ADR mainly involving skin and accessories,di gestive and circulation system.Conclusion Clinical ADR should pay attention to the work of abuse and report,and shall strengthen the antimicrobial application management,and try to reduce and avoid the happening of ADR.