阿奇霉素治疗小儿肺炎不良反应的分析

Analysis of Azithromycin in the treatment of adverse reaction of infants with pneumonia

目的探讨阿奇霉素治疗小儿肺炎的临床不良反应(ADR)的规律和特点。方法回顾2005年1月～2011年12月本院儿科静脉滴注阿奇霉素治疗小儿肺炎,所出现86例不良反应患儿进行统计分析。结果阿奇霉素所致ADR可累及全身各个系统,胃肠道系统损害占55.8%,皮疹占27.9%,过敏性休克占2.3%,循环系统损害占4.7%,神经系统损害占2.3%,泌尿系统损害占7.0%;男性占47.7%,女性占52.3%,ADR可发生于用药后的各个时间段。结论应重视阿奇霉素所致过敏性休克反应,加强监测,以减少不良反应的发生。

Objective To explore the rules and characteristics of Azithromycin in the treatment of adverse reaction of in fants with pneumonia.Methods Eighty-six cases of children with adverse caused by Azithromycin with Intravenous drip in the treatment of infants with pneumonia from January 2005 to December 2011 in pediatric department of our hospital,the adverse reactions were analyzed retrospectively.Results ADR caused by azithromycin could involved all systems in whole body,the incidence of gastrointestinal damage accounted for 55.8%,rash accounted for 27.9%,anaphylactic shock ac counted for 2.3%,circulatory system damage accounted for 4.7%,nervous system damage accounted for 2.3%,urinary sys tem damage accounted for 7.0%;Male accounted for 47.7%,female accounted for 52.3%.ADR could occur in different time after using drug.Conclusion It should pay attention to anaphylactic shock response induced by azithromycin,and strengthen monitoring to prevent reduce adverse events.