胰岛素泵联合小剂量胰岛素静脉滴注治疗糖尿病酮症酸中毒18例临床观察

Clinical observation of subcutaneous insulin infusion combined with low dose of insulin intravenous infusion in the treatment of 18 cases of patients with diabetic ketoacidosis

目的观察胰岛素泵联合胰岛素滴注治疗酮症酸中毒﹙DKA﹚的疗效。方法将2008年4月～2011年6月收治的DKA患者36例分为治疗组18和对照组18例,治疗组给予胰岛素泵全程治疗,结合小剂量胰岛素持续点滴,对照组给予小剂量胰岛素治疗。比较两组患者血糖变化、DKA纠正时间及住院时间。结果治疗组血糖下降相对稳定,酸中毒纠正时间短于对照组,且无反复;治疗过程中治疗组未出现低血糖,对照组出现3例;住院时间治疗组短于对照组。结论胰岛素泵联合胰岛素滴注治疗酮症酸中毒安全有效。

Objective To observe the curative effect of subcutaneous insulin infusion combined with insulin intravenous in fusion in the treatment of diabetic ketoacidosis（DKA）.Methods Thirty-six cases of patients with DKA,who were treated during April 2008 to June 2011 were divided into treatment group and control group with 18 cases each,treatment group patients were given subcutaneous insulin infusion combined with low dose of insulin intravenous infusion,the control group patients were given low dose of insulin intravenous infusion.Then the changes of blood glucose,DKA redress time and length of stay in two groups were compared.Results The blood glucose of the treatment group patients down relative stationarily,DKA redress time was shorter than that of control group,and it had no recurrence;during the course of therapy,none of the patients in treatment group occurred hypoglycemia,but there were 3 cases in the control group;the length of stay of the treatment group was shorter than that of control group.Conclusion Subcutaneous insulin infusion combined with insulin intravenous infusion is safe and effective to cure DKA.