胺碘酮治疗心力衰竭伴心律失常120例临床分析

Clinical analysis of Amiodarone in treatment of 120 cases of heart failure patients with arrhythmia

目的观察分析胺碘酮治疗心力衰竭伴心律失常的疗效。方法将120例心力衰竭伴心律失常患者随机分成两组,对照组57例,观察组63例。在患者没有服用其他抗心律失常药的前提下,两组均给予适量洋地黄、足量利尿剂、血管紧张素转换酶抑制剂、β受体阻滞剂抗心力衰竭治疗,观察组在此基础上口服胺碘酮。结果观察组的总有效率为93.6%,明显高于对照组的总有效率(P<0.01)。观察组在服用胺碘酮后出现3例恶心、食欲减退及便秘患者,但并没影响治疗,氨基转移酶升高1.5～4.0倍1例,两组均未出现严重不良反应。结论胺碘酮治疗心力衰竭伴心律失常安全有效,副作用小。

Objective To investigate and analyze the effect of Amiodarone in treatment of heart failure with arrhythmia. Methods One hundred and twenty cases of heart failure patients with arrhythmia were divided into observation group（63 cases） and control group （57 cases） respectively. On the premise of that all patients didn＇t take any other antiarrhythmic drugs, two groups were injected suitable digitalis, enough diureticum, angiotensin-converting enzyme inhibitor （ACEI） and β- receptor blocker against heart failure. On the basis of above drugs, patients of observation group were given Amiodarone oral. Results The total effective rate of observation group was 93.6%, the rate was higher than control group （P 〈 0.01）. Af- ter taken Amiodarone, 3 cases of observation group had nausea, anorexia and constipation, transaminase of 1 case increased about 1.5 to 4 times than before, but no severe adverse reactions in two groups were observed. Conclusion The Amio- darone is safe, effective and has little side-effect in treatment of heart failure with arrhythmia.