莫沙必利联合小剂量地西泮治疗功能性消化不良临床疗效分析

Clinical analysis of mosapride combined with low dose diazepam in treatment of functional dyspepsia

目的探讨莫沙必利联合小剂量地西泮治疗功能性消化不良的临床效果。方法选取2009年4月～2011年12月本院收治的功能性消化不良患者96例,随机分为对照组和观察组,每组各48例。对照组给予莫沙必利治疗,观察组给予莫沙必利的同时还有小剂量的地西泮进行治疗。观察比较两组临床症状,对上腹部疼痛,烧灼感,餐后胀满,早饱等情况进行症状评分。结果用药28d后,对照组治疗总有效率为66.7%,观察组为87.5%,两组比较,P<0.05,差异具有统计学意义。两组均无严重的不良反应,均未影响治疗。结论莫沙必利联合小剂量地西泮治疗功能性消化不良具有良好的临床效果,值得临床推广。

Objective To explore the clinical efficacy of 96 cases with functional dyspepsia treated by mosapride combined with low dose diazepam. Methods Ninety-six cases with functional dyspepsia lived in our hospital from April 2009 to De cember 2011 were selected and divided into the control group （48 cases） and tile observation group （48 cases）. The control group was treated by mosapride, and the observation group was treated by mosapride and low dose diazepam. The clinical symptom of the two groups was observed, upper abdominal pain, burning, postprandial fullness, early satiety symptoms scores were assessed. Results After 28 days, the total effective rate of the control group was 66.7%, the observation group was 87.5%, the difference between the two groups had statistically significant （P 〈 0.05）. The two groups both had no seri- ous adverse events, and didn＇t impact on the treatment. Conclusion It has better efficacy of mosapride combined with low dose diazepam in the treatment of functional dyspepsia, it＇s worthy for clinical.