川芎嗪注射液联合甘露醇治疗眩晕症61例的临床观察

Clinical observation of ligustrazine injection combined with mannitol in treatment of vertigo in 61 cases

目的观察川芎嗪联合20%甘露醇注射液治疗椎-基底动脉供血不足性眩晕症的临床疗效。方法将2008年6月～2011年12月诊治的椎-基底动脉供血不足性眩晕症患者61例随机分为两组。治疗组31例,采用川芎嗪注射液200mg加入液体中静滴,并联合使用20%甘露醇注射液250mL静滴。对照组30例,采用复方丹参注射液20mL加入液体中静滴、胞磷胆碱500mg加入液体中静滴。两组疗程均为7d。结果治疗组有效率为93.5%,对照组为83.3%,两组比较差异无统计学意义(P>0.05)。治疗组显效率为80.6%,对照组为30.0%,两组比较差异有统计学意义(P<0.05)。结论川芎嗪联合20%甘露醇注射液治疗椎-基底动脉供血不足性眩晕症疗效显著。

Objective To observe the clinical efficacy of ligustrazine combined with 20% mannitol injection in treatment of vertigo caused by vertebral-basilar artery insufficiency. Methods Sixty one cases of patients with vertigo caused by verte- bral-basilar artery insufficiency in our hospital from June 2008 to December 2011 were divided into two groups. 31 cases in the treatment group were treated with 200 mg ligustrazine injection added to liquid combined with 250 mL 20% manni- tol injection by intravenous drip. 30 cases in the control group were treated with 20 mL compound danshen injection com- bined with 500 mg citicoline added to liquid by intravenous drip. Course of treatment of the two groups were both 7 days. Results Effective rate of the treatment group was 93.5%, which of the control group was 83.3%, difference was not statisti- cally significant （P 〉 0.05）. Significant effective rate of the treatment group was 80.6%, which of the control group was 30.0%, the difference was statistically significant （P 〈 0.05）. Conclusion Efficacy of ligustrazine combined with 20% man- nitol injection in treatment of vertigo caused by vertebral-basilar artery insufficiency is remarkable