联合用药治疗2型糖尿病的临床疗效分析

Analysis of curative effect on combined medication in the treatment of type 2 diabetes

目的比较临床中常用药物治疗2型糖尿病的临床疗效,分析单独及联合应用降糖药在2型糖尿病中的治疗效果。方法抽取来本院内分泌科就诊的128例2型糖尿病患者,随机分为4组,A组单独给予黄酰脲类,B组单独使用双胍类,C组单独使用α-葡萄糖苷酶抑制剂,D组联合应用两种或者3种降糖药。结果 4种方法治疗2型糖尿病均有效果,A、B、C3组单独使用结果差异无统计学意义(P>0.05),治疗显效率分别为76.5%、74.2%、75.0%;但是3组与D组比较,差异有统计学意义(P<0.05),D组联合用药治疗显效率达85.7%,联合应用药物对于2型糖尿病患者治疗疗效显著。结论几种降糖药对于2型糖尿病均有疗效,但是根据患者具体情况联合应用治疗效果优于单独用药。

Objective To compare the clinical efficacy of clinical common drugs in the treatment of type 2 diabetes, and to analyze the treatment effects of single and combined application of hypoglycemie drugs in type 2 diabetes. Methods One hundred and twenty-eight cases of patients with type 2 diabetes admitted to endocrinology department of our hospital were chosen and randomly divided into four groups： group A was given ureide derivative only, group B was given biguanides alone, group C was given α-glucosidase inhibitors alone, group D was given combined application of two or three kinds of hypoglycemic drugs. Results The treatment of all the four methods in type 2 diabetes was effective. There were no statisti- cally significant differences of the single application of group A, B and C （P 〉 0.05）, the curative effect of which was 76.5%, 74.2%, 75.0% respectively; but there was significant difference among the three groups and the combined applica- tion of group D （P 〈 0.05）, the total effect of the combined application of group D reached to 85.7%. The combined medi- cation in the treatment of type 2 diabetes had remarkable curative effect. Conclusion Several hypoglycemic drugs for the treatment of type 2 diabetes are effective, but the effects of combined medication are more effective than used alone accord- ing to the specific circumstance of patients.