氯沙坦联合硝苯地平治疗高血压合并糖尿病疗效观察

Effective observation on losartan and nifedipine in the treatment of hypertension combined with diabetes

目的探讨氯沙坦联合硝苯地平治疗高血压合并糖尿病的临床疗效。方法将90例高血压合并糖尿病患者随机分成观察组和对照组各45例,两组均给予调节血糖、饮食控制、运动等常规治疗,对照组在常规治疗基础上给予氯沙坦治疗,观察组在常规治疗基础上给予氯沙坦联合硝苯地平缓释片治疗。两组患者于服药前和服药后3个月检测空腹血糖(FBG)、血肌酐(Scr)和尿微量白蛋白排泄率(UAER)的变化。结果观察组Scr和UAER改善程度显著好于对照组,差异有统计学意义(P<0.05)。观察组血压控制疗效显著优于对照组,差异有统计学意义(P<0.05)。两组均无明显并发症发生(P>0.05)。结论在常规血糖控制的基础上,氯沙坦联合硝苯地平治疗高血压合并糖尿病比单独应用缬沙坦治疗效果更好,值得临床推广。

Objective To discuss the efficacy of losartan and nifedipine in the treatment of hypertension combined with diabetes. Methods Ninety patients with hypertension combined with diabetes were divided into observation group and control group, each group had 45 cases, two groups were given conventional treatment such as blood sugar observation, diet control, and motion and so on, control group was given losartan based on the conventional treatment, observation group was given losartan and nifedipine based on the conventional treatment, the change of FBG, Scr, UAER of two groups were detected before taking the medicine and after taking the medicine in 3 months. Results Improve degree of Scr, UAER of two groups in observation group were better than that of control group, there was significant difference （P 0.05）. The effect of blood pressure control was better than that of control group （P 0.05）. There were no complications in two groups （P 0.05）. Conclusion Losartan and nifedipine in the treatment of hypertension combined with diabetes has better effect than the treatment of using the losartan base on the blood pressure control, so it is worthy to use in clinic.