血清超敏C-反应蛋白和同型半胱氨酸水平变化与冠心病关系研究

Relationship study between changes of serum levels of high-sensitive C-reactive protein, homocysteine and coronary heart disease

目的探讨超敏C反应蛋白(hs-CRP)及同型半胱氨酸(Hcy)的水平变化在冠状动脉粥样硬化心脏病中的临床意义。方法采用循环酶法和透射免疫比浊法,分别检测70例冠状动脉粥样硬化患者(观察组)和66例冠状动脉正常者(对照组)的hs-CRP和Hcy水平。结果观察组患者平均血清hs-CRP、Hcy明显高于对照组,两组比较差异有统计学意义(P<0.05);观察组病变部位血管腔面积大于对照组(P<0.05)。结论检测冠心病患者血清hs-CRP、Hcy水平对患者疾病预测及治疗具有重要的临床意义。

Objective To explore clinical significance of changes in serum levels of high-sensitive C-reactive protein （hs-CRP） and homocysteine （Hcy） in patients with coronary heart disease. Methods Hs-CRP and Hcy levels 70 cases with atherosclerosis （observation group） and 66 cases with normal coronary artery （control group） were respectively detected by the enzymatic cycling and transmission immunoturbidimetric assay. Results The mean serum level of hs-CRP in observation group was higher than that in control group,there was significant difference （P 0.05）. The lesion vessel area of observation group was bigger than that of control group （P 0.05）. Conclusion The detection of serum levels of hs-CRP and Hcy play an important role in disease prediction and treatment of patients with coronary heart disease.