升降汤治疗小儿慢性特发性血小板减少性紫癜临床疗效及T淋巴细胞亚群的研究

Study on Clinical Curative Effects of Hoisting Soup in the Treatment of Children With Chronic Idiopathic Thrombocytopenic Purpura

目的探讨升降汤加减对小儿慢性特发性血小板减少性紫癜(ITP)免疫调控作用、临床疗效及对T淋巴细胞亚群的影响。方法选择2008年8月至2011年12月于即墨市人民医院、青岛市市立医院及泰安市中医院就诊并确诊为小儿慢性ITP患儿44例为研究对象,随机将其分为治疗组(n=23)和对照组(n=21)。治疗组采用升降汤+泼尼松+辅助治疗,对照组仅使用泼尼松+辅助治疗(本研究遵循的程序符合即墨市人民医院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意)。检测2组患儿治疗前、后血清T淋巴细胞亚群、血小板(PLT)及骨髓巨核细胞计数。结果治疗后6个月治疗组患儿较对照组CD4+T细胞增加,CD8+T细胞减少,CD4+/CD8+增高,2组比较,差异有统计学意义(P<0.05);治疗组患儿临床疗效明显优于对照组,2组比较,差异有统计学意义(P<0.05)。结论小儿慢性ITP存在免疫功能紊乱,升降汤具有免疫调控作用,对小儿慢性ITP具有肯定疗效。

Objective To investigate immune regulation,clinical efficacy and T lymphocyte subsets of the hoisting soup in the treatment of chronic idiopathic thrombocytopenic purpura （ ITP ） in children. Methods From August 2008 to December 2011,a total of 44 cases with chronic ITP in People′s Hospital of Jimo City,Qingdao Municipal Hospital and Taian Chinese Medicine Hospital were included into this study. They were randomly divided into treatment group （ n=23 ） and control group （ n=21 ） .Informed consent was obtained from all participates.Treatment group received hoisting soup＋prednison＋adjunctive therapy,control group only received prednisone＋adjunctive therapy.The level of T lymphocyte subsets,platelet and megakaryocyte before and after the treatment were observed.Results CD 4 ＋ T cell and CD 4 ＋ / CD 8 ＋ in treatment group increased than those of control group after treating 6months,but CD 8 ＋ T cell in treatment group reduced than that of control group,there had significant difference between two groups （ P0.05 ） . Clinical effects between two groups also had significant difference after the treatment （ P 0.05 ） . Conclusions Children with chronic ITP presented immunologic functional disorder.Hoisting soup is of immune regulation effect,and reliable curative effects for chronic ITP children.