低分子肝素和丹参溶液联合治疗早发型重度子痫前期的疗效分析

Curative Effects of Low Molecular Weight Heparin and Salvia Miltiorrhiza on Early Onset Severe Preeclampsia

目的分析低分子肝素和丹参溶液治疗早发型重度子痫前期的疗效。方法选择2010年6月至2011年12月于本院就诊的75例早发型重度子痫前期患者为研究对象,并随机分为A组(n=18,常规治疗),B组(n=20,常规治疗+皮下注射低分子肝素),C组(n=19,常规治疗+静脉滴注丹参溶液)和D组(n=18,常规治疗+皮下注射低分子肝素+静脉滴注丹参溶液)(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书)。结果 A组产后7d出院率、转氨酶升高和低蛋白血症发生率与其余3组比较,差异均有统计学意义(P<0.05)。D组平均延长胎龄、平均出生体重与其余3组比较,差异也有统计学意义(P<0.05)。结论低分子肝素和丹参溶液联合治疗早发型重度子痫前期可延长孕龄、促进胎儿成长,改善母婴结局。

Objective To analysis the curative effects of low molecular weight heparin and salvia miltiorrhiza on early onset severe preeclampsia.Methods From June 2010to December 2011,75women with early onset severe preeclampsia were included in the study,and divided into group A （ n=18,routine treatment ）, group B （ n=20,routine treatment＋low molecular weight heparin ）, group C （ n=19,routine treatment＋salvia ） and group D （ n=18,routine treatment＋low molecular weight heparin＋ salvia ） .The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Chongqing Three Gorges Central Hospital.Informed consent was obtained from each patients.Results There were significant differences in the postpartum 7dhospital discharge rate,incidence of elevated liver enzymes and hypoproteinemia between group A and the other groups （ P0.05 ） .The prolong average gestational age and birth weight in group D was obviously higher than that of the other groups.Conclusions Low molecular weight heparin combined with salvia on early onset severe preeclampsia contributes to the improvement of materno-fetal outcomes.