厄贝沙坦治疗中青年高血压的临床疗效及依从性研究

Therapeutic effect of irbesartan on hypertension in young and middle -aged people and their treatment compliance

目的观察厄贝沙坦治疗中青年高血压的临床疗效及依从性。方法本组研究选择我院门诊收治的120例中青年高血压患者,将其随机分成两组进行。观察组患者为60例,服用厄贝沙坦(150毫克,每日一次)治疗;对照组患者为60例,予硝苯地平缓释片(20毫克,每日二次)治疗,随访8周,对其临床疗效以及依从性进行对比分析。结果 8周以后,观察组患者治疗的总有效率为96.67%,不良反应的发生率为3.33%;而对照组患者治疗的总有效率为83.33%,不良反应的发生率为6.67%。二者之间的差异具有显著性(P<0.05)。结论厄贝沙坦对于中青年高血压的治疗效果显著,且依从性好,是治疗中青年高血压的合理和有效的药物,值得临床推广。

Objective To observe the therapeutic effect of irbesartan on hypertension in young and middle- aged people and their treatment compliance. Methods A total of 120 young and middle-aged patients with hypertension, who received treatment in the outpatient department of our hospital, were randomly divided into observation group （n = 60） and control group （n = 60）. The observation group received therapy with irbesartan （150 mg, once daily）, while the control group received therapy with sustained-release tablets of nifedipine （20 rag, twice daily）. Follow-up was performed for 8 weeks for comparative analysis of therapeutic effect and treatment compliance. Results The observation group showed an overall response rate of 96.67% and an adverse reaction incidence of 3.33%, compared with 83.33% and 6.67% in the control group, demonstrating significant difference （P〈0.05）. Conclusion Irbesartan has good therapeutic effect on hypertension in young and middle-aged people, and the patients have good treatment compliance. Irbesartan holds promise for wide application in the treatment of hypertension in young and middle-aged people.