替餐干预对体重控制和糖脂代谢的影响

Effect of meal replacements on body weight control and blood glucose and lipid profile

目的应用替餐调整受试者膳食的营养素成分和数量，探讨替餐干预方法对体重的控制效果及其对糖脂代谢的影响。方法130例受试者按随机数字表法随机分配到试验组（100例）和对照组（30例）。在3个月的试验期内，对照组受试者仅接受常规饮食指导，试验组受试者除此以外每天用替餐代替两顿正餐。定期采集人体测量指标和实验室检测指标进行统计分析。结果与干预前比较，试验组受试者使用替餐12周后体重指数和腰围分别降低7．2％和6．5％（均P〈0．01），与同期对照组比较也有统计学意义（均P〈0．05）。同时，试验组受试者的收缩压、舒张压、空腹血糖和甘油三酯水平均显著下降（均P〈0．01），与同期对照组比较也有统计学意义（均P〈0．01）。结论替餐的使用有助于体重的控制，并对肥胖症可能合并的高血压或糖脂代谢异常有调整作用。

Objective To assess the effect of meal replacements on body weight control and blood glucose and lipid profile by adjusting their nutrients intake with a meal replacement approach. Methods One hundred and thirty subjects were randomly divided into intervention group （ 100 subjects ） and control group （ 30 subjects）. Besides dietary consulting and health education, all subjects in intervention group received a dietary treatment with 2 meal replacements each day over a shot-term （ 3 months）. All subjects were evaluated by recording the body measurements and laboratory data every 2 weeks. Results Compared with the baseline, mean percentages of BMI loss and decrease in waist circumference were 7.2 % and 6.5% for intervention group （P〈0.01） by week 12. Meanwhile, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, and triglyceride levels were significantly reduced （ P〈0.01 ）, showing significant difference compared with control group at the same period（ all P〈0.01 ）. Conclusion The meal replacement approach evaluated is an effective strategy to control body weight, and thus to achieve great improvement in the prevention of obesity-related diseases.