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胃癌中NPRL2和CHK1的表达及意义 被引量：1

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摘要 目的观察胃良、恶性病变组织中NPRL2和细胞周期检测点激酶1(CHK1)的表达及其临床病理意义。方法采用免疫组化SP法检测胃良、恶性病变组织中NPRL2和CHK1的表达,分析两者的表达水平与临床病理特征的关系以及两者表达的相互性。其中慢性浅表性胃炎20例,慢性萎缩性胃炎伴肠化32例,异型增生30例,胃癌50例。结果在慢性浅表性胃炎→慢性萎缩性胃炎伴肠化→异型增生→胃癌的过程中,CHK1的表达呈逐渐递增趋势,而NPRL2则逐步递减;NPRL2、CHK1表达均与浸润深度、分化程度、淋巴结转移明显相关,差异均有显著性(P<0.05);两者的表达与年龄、性别无关;胃癌组织中NPRL2和CHK1表达存在相关性(P<0.05)。Kaplan-Meier分析显示,CHK1阴性组2年生存率为72.2%,稍高于阳性组的56.2%(P>0.05);NPRL2阳性组2年生存率为83.3%,明显高于阴性组50%(P<0.01)。Cox回归多因素分析显示NPRL2表达是一独立预后因素。结论 NPRL2和CHK1表达水平可能是反映胃癌发生、进展、生物学行为及指导临床辅助治疗的重要生物学指标。NPRL2表达可作为评价胃癌预后的指标。
作者 赵艳 周建斌 李芳 张娜 周亚东 杨晶
机构地区 长沙市第四医院病理科
出处 《临床与实验病理学杂志》 CAS CSCD 北大核心 2012年第11期1273-1276,共4页 Chinese Journal of Clinical and Experimental Pathology
关键词 胃肿瘤 NPRL2 CHK1
分类号 R735.2 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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共引文献44

同被引文献16

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临床与实验病理学杂志
2012年 第11期

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