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发酵法生产硫酸软骨素的研究进展 被引量：5

Microbial production of chondroitin sulfate: a review
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摘要 硫酸软骨素是一种典型的硫酸化糖胺聚糖,具有多种药物活性,广泛应用于药品、保健品及化妆品行业。硫酸软骨素是动物软骨中蛋白聚糖的主要成分和少数几种细菌的荚膜多糖,因此可利用动物提取法和发酵法进行生产。以下综述了硫酸软骨素的发酵生产及其合成机制的研究进展,并对其发展趋势进行了展望。 Chondroitin sulfate （CS） is the typical sulfation glycosaminoglycan and widely applied in the industries of pharmaceutical, health products and cosmetic for its peculiar properties. CS is the main component of cartilage proteoglycans in animal and capsular polysaccharide in a few bacteria. CS can be extracted from animal sources and produced via microbial fermentation. In this article, development of chondroitin sulfate by fermentation, biosynthesis andregulating mechanisms of CS in bacteria are described. Furthermore, prospect and tendency of chondroitin sulfate from bacterial fermentation are addressed.
作者 吴秋林 刘立明 陈坚
机构地区 江南大学食品科学与技术国家重点实验室 江南大学工业生物技术教育部重点实验室 江南大学食品微生物制造工程实验室
出处 《生物工程学报》 CAS CSCD 北大核心 2012年第11期1281-1293,共13页 Chinese Journal of Biotechnology
基金 江苏省科技支撑计划项目(No.BE2012617) 中组部青年拔尖人才支持计划 江苏省杰出青年基金(No.BK2012002) 国家高技术研究发展计划(863计划)(No.2012AA022 108)资助~~
关键词 硫酸软骨素 发酵生产 合成途径 代谢调控 chondroitin sulfate, fermentation, synthesis pathway, metabolic regulation
分类号 TQ920.6 [轻工技术与工程—发酵工程]
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参考文献48

  • 1翟中和,王喜忠,丁明孝.细胞生物学.3版.北京:高等教育出版社,2008:528—529.
  • 2Zhou S. Health food useful for improving water content of skin, obtained by mixing components including hyaluronic acid, chondroitin sulfate, fish collagen, vitamin C powder, glycine, proline, extract of grape seeds and starch: CN, 102210425A, 2011-10-12.
  • 3Wada T, Mano T, Tanouchi M. Composition useful in pharmaceuticals and food-drinks for treating asthenopia, comprises mixture of chondroitin sulfate: WO, 2011136159A1, 2011-03-11.
  • 4Schiraldi C, Cimini D, DeRosa M. Production of chondroitin sulfate and chondroitin. Appl Microbiol Biotechnol, 2010, 87(4): 1209-1220.
  • 5Lauder R. Chondroitin sulphate: a complex molecule with potential impacts on a wide range of biological systems. Complement Ther Med, 2009, 17(1): 56-62.
  • 6Jolly JF, Klimaszewski K, Nakanishi Y, et al. Microbial-derived chondroitin sulfate: US, 20100063001A1, 2009-06-03.
  • 7Rrodriguez ML, Jann B, Jann K. Structure and serological characteristics of the capsular K4 antigen of Escherichia coli 05: K4: H4, a fructose-containing polysaccharide with a chondroitin backbone. Eur J Biochem, 1988, 177(1): 117-124.
  • 8Bedini E, DeCastro C, DeRosa M, et al. A microbiological-chemical strategy to produce chondroitin Sulfate A,C. Angew Chem Int Ed Engl, 2011, 50(27): 6160-6163.
  • 9DeAngelis PL, Gunay NS, Toida T, et al. Identification of the capsular polysaccharides of Type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively. Carbohydr Res, 2002, 337(17): 1547-1552.
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同被引文献84

  • 1张峥,耿芳宋,高华.猪软骨中硫酸软骨素的分离纯化[J].中国生化药物杂志,2004,25(3):144-146. 被引量：17
  • 2翟中和,王喜忠,丁明孝.细胞生物学[M].3版.北京:高等教育出版社,2008:284-285.
  • 3Zhou S. Health food useful for improving water content of skin, obtained by mixing components including hyaluronic acid, chondroitin sulfate, fish collagen, vitamin C powder, glycine,proline,extract of grape seeds and starch : CN, 102210425A [ P ]. 2011-10-12.
  • 4Wada T, Mano T, Tanouchi M. Composition useful in pharmaceuticals and food-drlnks fbr treating asthenopia, comprises mixture of chondroitin sulfate: WO, 2011136159A1 [ P ]. 2011- 03-11.
  • 5Schiraldi C, Cimini D, DeRosa M. Production of chondroitin sulfate and chondroitin [ J ]. Appl Microbiol Biotechnol, 2010,87 (4) : 1209-1220.
  • 6Lauder R.Chondroitin sulphate:a complex molecule with potential impacts on a wide range of biological systems [ J ]. Complement Ther Med,2009,17(1) :56-62.
  • 7DeAngelis P. Chondroitin synthase gene and methods of making and using same : US,7569386B2[ P ] .2005-06-24.
  • 8Rrodriguez M L, Jann B, Janu K. Structure and serological characteristics of the capsular K4 antigen of Escherichia coli 05 : K4:H4, a fi'uctose-containing p,,lysaccharide with a chondroitin backbone[ J] .Eur J Biochem, 1988,177( 1 ) : 117-124.
  • 9DeAngelis P L, Gunay N S, Toida T, et al. Identification of the capsular polysaccharides of type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively [ J ]. Carbohydr Res,2002,337(17) : 1547-1552.
  • 10Jolly J, Klimaszewski K, Nakanishi Y, et al. Microbial-derived chondroitin sulfate : US ,20100063001A1 [ P ] .2009-06-03.

引证文献5

二级引证文献27

生物工程学报
2012年 第11期

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