后抗生素时代我们如何征服细菌?

How to conquer bacteria in post-antibiotic era?

耐药性"超级细菌"的出现,将使我们重新步入无抗生素可用的时代,即"后抗生素时代"。面对日益严重的细菌耐药性,寻找新的抗菌药物及治疗方案已成为目前急需解决的难题。文章阐述新型抗生素、抗菌肽、噬菌体和中药制剂的研究开发及应用前景,为后抗生素时代针对耐药细菌,特别是超级细菌的抗感染药物的研究提供思路。

The occurrence of antibiotic resistant bacteria, especially pan-drug resistant bacteria may make no antibiotic~ available for the treatment of infectious diseases, which will lead to the emerge of post-antibiotic era. It is imperative to tim new antibacterial drugs or strategies to solve the increasingly serious problem of drug resistance. The invention status am application prospect of new-type antibiotics, antimicrobial peptide, bacteriophage and traditional Chinese medicim preparation are introduced in this paper, which may provide reference for the exploration of antibacterial drugs to conque bacteria in post-antibiotic era.