盐酸沙格雷酯治疗慢性下肢动脉缺血的疗效观察

Sarpogrelate hydrochloride in the treatment of chronic arterial ischemia of the lower extremities

目的 评价盐酸沙格雷酯治疗慢性下肢动脉缺血的临床疗效.方法 选择未施行血管移植或血管旁路搭桥手术或（和）介入治疗的动脉粥样硬化、血栓闭塞性脉管炎、糖尿病足伴有下肢间歇性跛行、冷感、疼痛、溃疡等缺血症状的患者892例为治疗对象.盐酸沙格雷酯剂量为100 mg/次,3次/d,疗程为8周.观察用药前后的症状改善程度、综合疗效以及药物不良反应.结果 间歇性跛行、冷感、疼痛、溃疡的改善率分别为96.9％、97.1％、89.0％和86.9％,3种疾病总有效率（显效＋良好）83.5％.81例（9.1％）有轻度不良反应,7例皮疹,21例轻度恶心,53例胃部不适,对症治疗后可缓解,不需停药.结论 盐酸沙格雷酯治疗慢性下肢动脉缺血性疾病是一种安全、有效的药物.

Objective To evaluate the clinical efficacy of oral Sarpogrelate hydrochloride in the treatment of chronic arterial ischemia of the lower extremities.Methods In this study 892 patients,who suffered from arteriosclerosis （ASO） or thromboangiitis obliterans （ TAO ） or diabetic foot （ DF ）,with symptoms of intermittent claudication, sensation of cold, pain, ulcer, and without a history of vasotransplantation or bypass grafting or interventional therapy, were treated by taking Sarpogrelate hydrochloride tablets 100 mg tid for consecutive 8 weeks.The improvement rate of concomitant symptoms and the total effective rate of ASO, TAO, DF were evaluated.Drug adverse reaction were recorded.Results The improvement rate of intermittent claudication,sensation of cold,pain and ulcer were 96.9%,97.1%,89.0% and 86.9% respectively.The total effective rate for ASO,TAO,DF was 83.5%.A total of 81 cases （9.1%） reported mild side effects,including 7 patients with mild rash after 2- 5 days＇ medication,21 patients with mild nausea and 53 patients with stomach discomfort after 1 - 2 days＇ medication.Symptoms were managed conservatively without discontinuing taking sarpogrelate hydrochloride.Conclusions Sarpogrelate hydrochloride oral is a safe and effective therapy for chronic arterial ischemia diseases of the lower extremities. Objective To evaluate the clinical efficacy of oral Sarpogrelate hydrochloride in the treatment of chronic arterial ischemia of the lower extremities.Methods In this study 892 patients,who suffered from arteriosclerosis （ASO） or thromboangiitis obliterans （ TAO ） or diabetic foot （ DF ）,with symptoms of intermittent claudication, sensation of cold, pain, ulcer, and without a history of vasotransplantation or bypass grafting or interventional therapy, were treated by taking Sarpogrelate hydrochloride tablets 100 mg tid for consecutive 8 weeks.The improvement rate of concomitant symptoms and the total effective rate of ASO, TAO, DF were evaluated.Drug adverse reaction were recorded.Results The improvement rate of intermittent claudication,sensation of cold,pain and ulcer were 96.9%,97.1%,89.0% and 86.9% respectively.The total effective rate for ASO,TAO,DF was 83.5%.A total of 81 cases （9.1%） reported mild side effects,including 7 patients with mild rash after 2- 5 days＇ medication,21 patients with mild nausea and 53 patients with stomach discomfort after 1 - 2 days＇ medication.Symptoms were managed conservatively without discontinuing taking sarpogrelate hydrochloride.Conclusions Sarpogrelate hydrochloride oral is a safe and effective therapy for chronic arterial ischemia diseases of the lower extremities.