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他克莫司在非感染性葡萄膜炎及实验性自身免疫性葡萄膜炎治疗中的应用及展望 被引量：2

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摘要 他克莫司为一种新型强效的免疫抑制剂，通过与内源性细胞内受体胞浆结合蛋白FKBP-12结合，阻断淋巴因子基因转录从而抑制T淋巴细胞活化。他克莫司口服给药对治疗非感染性葡萄膜炎效果显著，眼局部应用脂质体、控释药膜、植人体等制剂，局部给药治疗实验性自身免疫性葡萄膜炎均有较好疗效。其中，FKS06缓释制剂经巩膜给药可能有良好的应用前景。这些制剂的临床应用及其效果，尚需更多的经验积累。
作者 徐宇 赵春晖 程凌云
机构地区 温州医学院眼视光学院眼科药物研究所
出处 《中华眼底病杂志》 CAS CSCD 北大核心 2012年第6期653-656,共4页 Chinese Journal of Ocular Fundus Diseases
基金 国家自然科学基金（31271022） 浙江省省级重点科技创新团队项目（2009R50039） 温州市科技计划项目（Y20100077）
关键词 葡萄膜炎 治疗 他克莫司结合蛋白质类 药物作用 综述
分类号 R773.9 [医药卫生—眼科]
  • 相关文献

参考文献34

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二级参考文献9

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共引文献4

同被引文献24

  • 1张震,杨培增,周红颜,俞琼,黄祥坤,李兵.幼年型慢性关节炎伴发葡萄膜炎患者的临床特征和诊断及治疗[J].中华眼科杂志,2005,41(4):346-349. 被引量：7
  • 2孙明霞,陈家祺,陈龙山,林跃生,黄挺,周世有,刘永民,费文雷.真菌性角膜炎治疗性角膜移植术后局部应用FK506的临床评价[J].眼科研究,2005,23(6):640-643. 被引量：2
  • 3Li J, Heinz C, Zurek - Imhoff B . Intraoperative intraocular triamci- nolone injection prophylaxis for post - cataract surgery fibrin forma- tion in uveitis associated with juvenile idiopathic arthritis [ J ]. Journal of Cataract and Refractive Surgery , 2006. 32.9.
  • 4Knickelbein JE,Hendricks RL,Charukamnoetkanok P.Management of herpes simplex virus stromal keratitis:an evidence-based review[J].Surv Ophthalmol,2009,54 (2):226-234.doi:10.1016/j.survophthal.2008.12.004.
  • 5Iwamoto H,Yoshida H,Yoshida O,et al.Inhibitory effects of FK506 on the development of experimental allergic/immune-mediated blepharoconjunctivitis in Lewis rats by systemic but not by topical administration[J].Graefe's Arch Clin Exp Ophthalmol,1999,237 (5):407-414.doi:10.1007/s004170050252.
  • 6Souto-Rodríguez R,Molina-Pérez E,Castroagudín JF,et al.Differences in the incidence and clinical evolution of early neurotoxicity after liver transplantation based on tacrolimus formulation used in the immunosuppressive induction protocol[J].Transplant Proc,2014,46(9):3117-3120.doi:10.1016/j.transproceed.2014.10.006.
  • 7Reinhard T,Reis A,Mayweg S,et al.Topical Fk506 in inflammatory corneal and conjunctival diseases.A pilot study[J].Klin Monatsbl Augenheilkd,2002,219(3):125-131.doi:10.1055/s-2002-26727.
  • 8Simard-Lebrun A,Boisjoly H,Al-Saadi A,et al.Association between unilateral quiescent stromal herpetic keratitis and bilateral dry eyes[J].Cornea,2010,29 (11):1291-1295.doi:10.1097/ICO.0b013e3181 cbf9f5.
  • 9Stevenson D,Tauber J,Reis BL.Efficacy and safety of cyclosporin A ophthalmic emulsion in the treatment of moderate-to-severe dry eye disease:a dose-ranging,randomized trial.The Cyclosporin A Phase 2 Study Group[J].Ophthalmology,2000,107 (5):967-974.doi:10.1016/S0161-6420 (00) 00035-X.
  • 10Zhai J,Gu J,Yuan J,et al.Tacrolimus in the treatment of ocular diseases[J].BioDrugs,2011,25 (2):89-103.doi:10.2165/11587010-000000000-00000.

引证文献2

二级引证文献14

中华眼底病杂志
2012年 第6期

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