浸润性膀胱癌不同治疗方案预后的Meta分析

Meta Analysis of Prognosis for Patients with Invasive Bladder Cancer after Receiving Two Different Therapy Programs

目的探讨保留膀胱手术后灌注化疗与膀胱全切术对浸润性膀胱癌预后的效果差异性。方法利用Medline、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库等,检索国内外已发表的相关文献并进行评估,提取资料后对行保留膀胱手术后灌注化疗或膀胱全切术的浸润性膀胱癌患者5年生存率进行Meta分析。结果计算两种治疗方案检验统计量Z=1.22,P=0.22,差异无统计学意义,总体相对危险度的95%可信区间为(0.94～1.29)。结论对于浸润性膀胱癌患者,局部切除加灌注化疗5年生存率与全切组无差别,可以谨慎地接受保留膀胱策略,提高患者生存质量。

Objective To explore the effects of two different therapy programs on prognosis of invasive bladder cancer patients.Methods Related papers in Medline,Chinese Biological Medicine Database,China Journal Fulltext Database and China Scientific Journal Database were searched,then these papers were assessed,and the 5-year survival rates of invasive bladder cancer patients after receiving bladder preserving resection plus systemic chemotherapy or radical cystectomy were analyzed by using Meta analysis.ResultsThe test statistics was Z=1.22,P=0.22,it was considered as ＂nonsignificant＂ result at the 5% level according to its P-value.Conclusion There is a no difference between bladder preserving resection plus systemic chemotherapy and radical cystectomy for invasive bladder cancer patients,and choosing a bladder reservation program modestly may be helpful for improve the patients′ living quality.