瑞舒伐他汀对老年冠心病伴高脂血症患者血脂及高敏C反应蛋白的影响

Effect of Rosuvastatin on Serum Lipids and hs-CRP of Aged Patients with Coronary Heart Disease and Hyperlipidemia

目的探讨瑞舒伐他汀对老年冠心病伴高脂血症患者血脂及高敏C反应蛋白的影响。方法采用对照研究的方法,将72例患者随机分为治疗组(36例)和对照组(36例),治疗组服用瑞舒伐他汀钙片10 mg/d。观察治疗前后的血脂(TC、TG、LDL-C、HDL-C)及hs-CRP。结果治疗组治疗后较治疗前的TC、TG、LDL-C、hs-CRP明显下降,HDL-C升高(P<0.05)。治疗组治疗后较对照组治疗后的TC、TG、LDL-C、hs-CRP明显下降,HDL-C升高(P<0.05)。对照组治疗前后的血脂各指标及hs-CRP比较,差异无统计学意义(P>0.05)。结论瑞舒伐他汀可以使老年冠心病伴高脂血症患者的TC、TG、LDL-C、hs-CRP下降,HDL-C升高。

Objective To explore the effect of rosuvastatin on serum lipids and high sensitive C-reactive protein(hs-CRP) in aged patients with coronary heart disease(CHD) and hyperlipidemia. Methods Seventy-two patients with CHD and hyperlipidemia were investigated by case-control study.They were randomly divided into treatment group and control group(each n=36).The patients in the control group received conventional therapy,while the patients in the treatment group were given rosuvastatin 10 mg/d for 8 weeks in addition to the conventional treatment.The levels of serum TC,TG,LDL-C,HDL-C and hs-CRP were observed before and after the treatment. Results After 8 weeks of treatment,the levels of serum TC,TG,LDL-C and hs-CRP in the treatment group were decreased significantly,while the level of HDLC was increased(P<0.05).After 8 weeks' treatment,the levels of TC,TG,LDL-C and hs-CRP in the treatment group were significantly lower than those in the control group,meanwhile,the level of HDL-C in the treatment group was higher than that in the control group(P<0.05).Before and after the treatment,all these indicators in the control group showed no statistically significant difference(P>0.05). Conclusions Rosuvastatin can decrease the levels of serum TC,TG,LDLC,hs-CRP and increase the level of HDL-C in aged patients with CHD and hyperlipidemia.