摘要
测定了天津市第一中心医院自1996年1月-1998年12月收治的56例肺癌患者和60例健康者(对照组)血清锌、铜含量和铜/锌比值,发现肺癌组锌明显低于对照组,铜与血清铜/锌比值明显高于健康对照组(P均<0.001)。还发现肺癌组按TNM分期,其铜与铜/锌比值各期均较对照组明显增高,且随病情进展而增高,即 Ⅳ期>Ⅲ期> Ⅱ期>Ⅰ期。并以铜1.91×10^(-6),铜/锌比值 1.38为临界值,发现其特异性分别为87%和88%,敏感性分别为 88.33%和 81.66%。同时在56例肺癌患者中有36例同时测定了CEA,阳性者14例,其阳性率仅为38.8%。提示血清锌、铜.与铜/锌比值对肺癌的诊断及疗效观察和预后判断具有一定的临床意义。
The serum zinc, copper and Cu/Zn ratio were determined in 56 lung cancer patients and 60 healthy people from JAN 1996 to DEC 1998. The value of serum Zn in lung cancer group was much lower than that in the control group while the Cu and Cu/Zn ratio were much higher than those in control group (P <0.001) and increased with escalation of disease from stage Ⅰto Ⅳ.Taking values of Cu 1.91×10^(-6) and Cu/Zn ratio 1.38 as levels of demarcation, the respective specificties were 87% and 88%. As compared with CEA value measurements of Cu, Cu/Zn ratio might contribute to the diagnosis, follow-up observation, therapeutic effect and assessment of the prognosis as well.
出处
《广东微量元素科学》
CAS
2000年第1期19-22,共4页
Trace Elements Science