血清锌、铜与铜/锌比值对肺癌诊断、疗效和预后判断的临床意义

Significance of Determination of Serum Zinc, Copper and Copper/Zinc Ratio on Evaluating Diagnosis Therapeutic Effect and Prognosis of Lung Cancer

测定了天津市第一中心医院自１９９６年１月－１９９８年１２月收治的５６例肺癌患者和６０例健康者（对照组）血清锌、铜含量和铜／锌比值，发现肺癌组锌明显低于对照组，铜与血清铜／锌比值明显高于健康对照组（Ｐ均＜０．００１）。还发现肺癌组按ＴＮＭ分期，其铜与铜／锌比值各期均较对照组明显增高，且随病情进展而增高，即 Ⅳ期＞Ⅲ期＞ Ⅱ期＞Ⅰ期。并以铜１．９１×１０^(－６)，铜／锌比值 １．３８为临界值，发现其特异性分别为８７％和８８％，敏感性分别为 ８８．３３％和 ８１．６６％。同时在５６例肺癌患者中有３６例同时测定了ＣＥＡ，阳性者１４例，其阳性率仅为３８．８％。提示血清锌、铜．与铜／锌比值对肺癌的诊断及疗效观察和预后判断具有一定的临床意义。

The serum zinc, copper and Cu/Zn ratio were determined in 56 lung cancer patients and 60 healthy people from JAN 1996 to DEC 1998. The value of serum Zn in lung cancer group was much lower than that in the control group while the Cu and Cu/Zn ratio were much higher than those in control group (P <0.001) and increased with escalation of disease from stage Ⅰto Ⅳ.Taking values of Cu 1.91×10^(-6) and Cu/Zn ratio 1.38 as levels of demarcation, the respective specificties were 87% and 88%. As compared with CEA value measurements of Cu, Cu/Zn ratio might contribute to the diagnosis, follow-up observation, therapeutic effect and assessment of the prognosis as well.