摘要
为探讨乙型肝炎表面抗原（ｈｅｐａｔｉｔｉｓ Ｂ ｓｕｒｆａｃｅ ａｎｔｉｇｅｎ， ＨＢｓＡｇ）阳性母亲的婴儿乙肝疫苗注入后早期机体免疫反应的特点，采用化学发光法测定了吞噬细胞的吞噬功能；用双抗原夹心法测定了抗－ＨＢｓ抗体。结果表明，（１）乙肝疫苗注入前两组间吞噬细胞的吞噬功能无明显差异，疫苗注入后３个月和６个月时实验组外周血吞噬细胞的吞噬功能明显下降（Ｐ＜０．０５）。两组间同时间点相比，１个月和３个月都有显著性差异（Ｐ＜０．０１，Ｐ＜０．０５）。（２）乙肝疫苗注入后各时间点抗－ＨＢｓ阳转率两组间无明显差异。可见 ＨＢｓＡｇ阳性母亲的婴儿接受乙肝疫苗注入后，早期机体免疫反应的变化与健康母亲的婴儿确有不同，两者外周血吞噬细胞吞噬功能的变化表现不同的规律。
The characters of early immune response on the infants whose mothers with hepatitis B surface antigen (HBsAg) after hepatitis B vaccination were studied. The cellular phagocytosis was examined by luminolenhanced chemiluminescence assay, and the anti-HBs was examined by the double antigen sandwich technique. The results showed that (1) The cellular phagocytosis showed no significant difference between the two groups before hepatitis B vaccination, and after hepatitis B vaccination it decreased obviously in 3rd and 6th month in infants born to mothers with HBaAg (P <0.05). In 1st and 3rd month there was significant difference between the two groups (P <0.01, P<0.05). (2) The ant-HBs positive rate in infant born to mothers with HBsAg did not differ from that of the controls significantly in the same time after hepatitis B vaccination. The characters of early immune response to hepatitis B vaccine are different between the infants born to mothers with HBsAg and those born bo health mothers, and the infants of two groups represented defferential law in cellular phagocytosis.
出处
《广东微量元素科学》
CAS
2000年第1期60-63,共4页
Trace Elements Science
