肿瘤标记物联合检测在胆囊良恶性病变诊断中的价值

Clinical significance of combined testing of serum tumor markers in the diagnosis of gallbladder carcinoma.

目的观察血清肿瘤标记物在胆囊疾病中的表达,分析血清肿瘤标记物联合检测在胆囊疾病诊断中的作用。方法选取我院2008年1月至2009年4月收治的胆囊癌患者25例(观察组),采用酶联免疫吸附法测定血清AFP、CEA和Fer的表达,并设同期收治的20例胆囊息肉患者为对照组,对比两组患者肿瘤标记物联合检测差异及临床诊断价值。结果观察组血清肿瘤标记物中Fer和CEA较对照组显著升高,组间比较差异有统计学意义(P<0.05),对胆囊癌诊断有较高价值,而AFP两组患者差异无统计学意义。平行法联合检测诊断胆囊癌的灵敏度为88%,系列法联合检测法诊断胆囊癌特异为95%。结论血清Fer和CEA联合检测对胆囊癌的诊断具有临床价值,联合检测可以增加诊断的特异度和灵敏度。

Objective To investigate the expression of serum tumor markers in patients with gallbladder carcinoma and to analyze the significance of combined testing of serum tumor markers in the diagnosis of gallbladder carcinoma. Methods A total of 25 patients with gallbladder carcinoma （the study group） admitted to our hospital from January 2008 to April 2009 were detected for the expression of AFP, CEA and Fer by enzyme linked immunosorbent assay （ELISA）. Twenty patients with gallbladder polypi admitted in the same period were selected as the control group. The clinical value of combined testing of tumor markers were compared between the two groups. Results The levels of Fer and CEA in study group were significantly higher than those in the control group （P0.05）, which had higher value for the diagnosis of gallbladder carcinoma. There is no statistical difference in AFP between two groups. Parallel combined testing can raise the sensitivity for gallbladder carcinoma to 88%, while serial combined testing can increase the specificity to 95%. Conclusion Combined testing of serum Fer and CEA has great clinical values for the diagnosis of gallbladder carcinoma, with improved specificity and sensitivity.