HPV感染和临床相关资料与舌根癌预后关系的初步研究

Correlation of HPV infection and related clinical data with the prognosis of tongue base carcinoma

目的评估HPV感染和临床相关资料对舌根癌预后的影响。方法记录56例舌根癌患者的相关临床资料,包括诊断时年龄、性别、TNM分期、复发与否、治疗方案和死亡原因,并对其中51例患者运用聚合酶链式反应(Polymerase chain reaction,PCR)检测其HPV感染状态,统计分析HPV感染和临床相关资料与预后的关系。结果年龄越小则预示患者预后较好(P=0.015)。HPV阳性的肿瘤患者,其存活率有显著变好的趋势,但未能达到统计学意义(P=0.140)。此外,通过多元分析发现年龄(P=0.004)是独立的预后影响因子。结论年龄在临床上可用作评估舌根癌预后的指标。

Objective To study the correlation of HPV and related clinical data with the prognosis of tongue base carcinoma. Methods The clinical data was collected from 56 patients of tongue base carcinoma, including age at diagnosis, gender, TNM stage, relapse, treatment and cause of death. Fifty-one of the 56 patients were tested for HPV by polymerase chain reaction （PCR）. The data were statistically analyzed. Results Younger patients were found to have better prognosis （P=0.015）. Patients with HPV-positive were found to have a better disease-specific survival, but this did not reach statistical significance （P=0.140）. Furthermore, multivariate analysis showed that age was the independent influence factor of the prognosis （P=0.004）. Conclusion Age could be used as an independent factors in the evaluation of the prognosis.