尿激酶治疗急性脑梗死不同时间段的量效关系研究

Dose-effect study of urokinase in the treatment of acute cerebral infarction at different time

目的探讨急性脑梗死患者不同时间段使用尿激酶治疗的量效关系。方法选取我院收治的急性脑梗死患者40例,按照治疗时间不同分为早期治疗组(发病<6h)和对照组(发病>6h),两组再分别设两个亚组,高剂量尿激素和低剂量尿激素治疗组。分别比较两组患者中高剂量和低剂量组的治疗后的神经功能缺损评分,治疗有效率和并发症情况。结果早期治疗组的高剂量组比低剂量组神经功能缺损评分低,治疗有效率高,并发症情况较少;对照组的低剂量组比高剂量组神经功能缺损评分低,治疗有效率高,并发症情况较少。差异均有统计学意义(P<0.05)。结论在急性脑梗死发病早期使用高剂量尿激素治疗效果好,治疗较迟者使用低剂量尿激素治疗效果好。

Objective To study the dose-effect of urokinase in the treatment of acute cerebral infarction at different time. Methods Forty patients of acute cerebral infarction were selected and divided into two groups, the early treatment group （received treatment within 6 hours after onset） and the control group （6 hours after onset）. The two groups were further divided into two subgroups, the high dose urokinase treatment group and low dose urokinase treatment group. Neurological function, the effective rate of the treatment and complications were compared between different groups. Results In the early treatment group, compared with the low dose urokinase treatment group, the high dose urokinase treatment group had lower neurological function score, higher effective rate and fewer complications, while the situation was reverse in the control group. The differences was statistically significant （P0.05）. Conclusion High dose urokinase treatment is better for the patients received treatment within 6 hours after onset, while low dose urokinase treatment is better for those received treatment 6 hours after onset.