妊娠期肝内胆汁淤积症对妊娠结局的影响

Effect of intrahepatic cholestasis on the pregnancy outcome of 64 pregnant women

目的探讨妊娠期肝内胆汁淤积症对妊娠结局的影响。方法选择2010年9月至2011年9月间我院产科诊治的妊娠期肝内胆汁淤积症患者64例为观察组,同期65例未合并肝内胆汁淤积症的妊娠期女性为对照组。观察并比较两组间患儿结局及两组间围产期并发症发生情况。结果 (1)观察组中发生羊水污染、胎儿宫内窘迫、新生儿窒息、早产儿及低体重儿的比例分别为25.00%、20.31%、17.19%、31.25%和15.63%,均显著高于对照组(P<0.05)。(2)观察组中妊高征、胎膜早破及产后出血的比例分别为21.88%、14.06%和14.06%,均显著高于对照组的7.69%、3.08%和3.08%,其差异均有统计学意义(P<0.05)。结论妊娠期肝内胆汁淤积症患者围产期并发症发生率高,围产期患儿预后差,应该采取积极的预防和治疗措施。

Objective To study the effect of gestational intrahepatic cholestasis on pregnancy outcome. Methods Sixty-four pregnant women with intrahepatic cholestasis were chosen as the study group, and 65 pregnant women without intrahepatic cholestasis were chosen as the control group. The pregnancy outcome and the perinatal complications were observed and compared between the two groups. Results The incidence of amniotic fluid contamination, fetal distress, asphyxia, premature children and low birth weight infants in the study group were 25.00%, 20.31%, 17.19%, 31.25% and 15.63%, respectively, significantly higher than those of the control （P0.05）. The incidence of pregnancy-induced hypertension and premature rupture of membranes, postpartum hemorrhage in the study group were 21.88%, 14.06% and 14.06%, respectively, significantly higher than the control （7.69%, 3.08% and 3.08%）, P0.05. Conclusion Pregnant women with intrahepatic cholestasis tend to have high incidence of perinatal complications and poor perinatal outcome. Measures should taken for active prevention and treatment.