莫西沙星治疗老年卒中相关性肺炎疗效调查

Efficacy of moxifloxacin in treatment of stroke-associated pneumonia in the elderly

目的评估莫西沙星治疗老年卒中相关性肺炎的有效性及安全性,为治疗老年卒中相关性肺炎选择安全、有效的抗菌药物。方法将2008年1月-2010年12月在医院呼吸内科住院的63例老年卒中相关性肺炎患者随机分为两组,治疗组33例给予莫西沙星,对照组30例给予头孢他啶,观察临床疗效及其不良反应。结果治疗组与对照组临床有效率、细菌清除率分别为87.87%、88.00%和73.33%、64.29%;两组临床有效率和细菌清除率差异有统计学意义(P<0.05);治疗组的不良反应为9.09%。结论莫西沙星治疗老年卒中相关性肺炎效果满意,不良反应少,是治疗老年卒中相关性肺炎安全、有效的抗菌药物。

OBJECTIVE To evaluate the effectiveness and safety of moxifloxacin in the treatment of stroke-associated pneumonia in the elderly so as to provide safe and effective antibiotics for the treatment of stroke-associated pneumonia.METHODS A total of 63 elderly patients with stroke-associated pneumonia,who enrolled the respiratory medicine department of the hospital from Jan 2008 to Dec 2010,were randomly divided into two groups,33 cases in the treatment group were treated with moxifloxacin,and 30 cases in the control group were treated with ceftazidime.The clinical efficacies and the adverse reactions of the two groups were observed.RESULTS The clinical effective rates of the treatment group and the control group were 87.87% and 73.33%,respectively,and the bacterial clearance rates of the treatment group and the control group were 88.00% and 64.29%,respectively,the differences were statistically significant（P0.05）.The incidence of the adverse reactions was 9.09% in the treatment group.CONCLUSION The moxifloxacin can achieve satisfied effect on the treatment of stroke-associated pneumonia,with producing less adverse reactions,which is a kind of safe and effective antibiotics for the treatment of stroke-associated pneumonia in the elderly.