鲍氏不动杆菌的分布及耐药性分析

Distribution and antibiotic resistance of Acinetobacter baummanii

目的调查医院鲍氏不动杆菌分布及耐药性变化,为临床合理用药提供依据。方法收集2008年6月-2011年6月3所医院细菌室分离的鲍氏不动杆菌,采用纸片扩散法作药敏试验。结果 3年共分离鲍氏不动杆菌503株,分布率在呼吸科最高,其次为ICU,分别为27.24%、21.87%;痰标本分离的鲍氏不动杆菌最多见,占81.71%,其次是伤口分泌物占12.13%;鲍氏不动杆菌的分离率在3年内逐年增加,依次为19.50%、21.71%、29.28%;鲍氏不动杆菌对多种抗菌药物的耐药率均较高,对多数抗菌药物的耐药率>50.00%,耐药率<50.00%仅有多黏菌素B、头孢哌酮/舒巴坦、阿米卡星、妥布霉素、米诺环素。结论 3所医院鲍氏不动杆菌对多种抗菌药物具有耐药性,应根据药敏结果合理使用抗菌药物。

OBJECTIVE To analyze the distribution and antimicrobial resistance of Acinetobacter baummanii so as to provide basis for the clinical reasonable use of antibiotics.METHODS A.baummanii were collected in 3 hospitals from June 2008 to June 2011.Antimicrobial susceptibility testing was performed by disk-diffusion method.RESULTS A total of 503 A.baummanii were collected during 3 years.Of these isolates,137（27.24%） strains were from the department of respiratory,110 strains（21.87%） from intensive care unit.Most of the strains（81.71%）were isolated from sputum,followed by the wound secretions;the prevalence of A.baummanii was increasing during last 3 years,which were 19.50%,21.71%,and 29.28%,respectively;the results of susceptibility testing showed that the resistance rates were high to most antibiotics,the resistance rates to most antimicrobial agents were more than 50.0%,only the drug resistance rates to polymyxin B,cefoperazone/sulbactam,amikacin,tobramycin,and minocycline were less than 50.0%.CONCLUSION A.baummanii isolates show high resistance to multiple antibiotics,it is necessary to reasonably use antibiotics on the basis of drug susceptibility testing.