血浆(1,3)-β-D葡聚糖在诊断侵袭性真菌感染的荟萃分析

Meta analysis of (1,3)-β-D-glucan in diagnosis of invasive fungal infections

目的通过荟萃分析系统评价血浆(1,3)-β-D葡聚糖在诊断侵袭性真菌感染的诊断价值。方法按照系统评价的要求检索CNKI数据库等,获得12篇符合纳入标准的文献,患者共2884例,对其进行荟萃分析,并评价荟萃分析结果的稳定性和发表偏倚。结果血浆(1,3)-β-D葡聚糖诊断侵袭性真菌感染的研究资料具有同质性(异质性检验χ2=15.17,P=0.17,I2=28%),因此,合并效应量OR采用固定效应模型,OR合并=2.02,其95%CI=1.81～2.25,总体效应检验,差异有统计学意义(Z=12.49,P<0.01);试验组检出率高于对照组。结论从现有的临床证据来看,血浆(1,3)-β-D葡聚糖是诊断侵袭性真菌感染的有效方法,起到辅助临床诊断作用。

OBJECTIVE To evaluate value of（1,3）-β-D-glucan in diagnosis of invasive fungal infections through the meta-analysis system.METHODS Totally 12 studies consistent with the inclusion standards were searched from CNKI,2884 subjects were included and analyzed synthetically by Meta-analysis system,then the stability of the result and the publication bias were evaluated.RESULTS The results of heterogeneity tests showed the data of（1,3）-β-D-glucan applied in the diagnosis of invasive fungal infections was homogeneity（heterogeneity testsχ2=15.17,P=0.17,I2=28%）.The combined OR should be analyzed with fixed effect mode.The combined OR=2.02,95%CI was from 1.81 to 2.25,the gross data analysis showed that the difference in the overall effect was statistically significant（Z=12.49,P0.01）.The detection rate of the experimental group was higher than that of the control group CONCLUSION The clinical evidence indicates that the（1,3）-β-D-glucan is an effective method to diagnose the invasive fungal infections,which can be widely introduced and applied in the clinical auxiliary examination.