摘要
Two novel rare earth tungstosilicic polyoxometalate containing 5-fluorouracil,K26(C4H4FN2O2)8Pr(SiW11O39)4·10H2O(FPSW) and K26(C4H4FN2O2)8Sm(SiW11O39)4·9H2O(FSSW),were synthesized and their structure were characterized by using elemental analysis,FTIR spectra,X-ray powder diffraction and TG.The antitumor activity tests of the compounds FPSW and FSSW were carried out by the methyl thiazolyl tetrazolium method in hepatocellular carcinoma cell HepG-2.The results showed that FPSW and FSSW could inhibit the HepG-2 cells in vitro significantly.The EC50 of FPSW and FSSW is 1.94×10-5 and 1.32×10-5 mol·L-1 respectively.The therapeutic index of FPSW and FSSW is 0.76 and 1.58 respectively.
Two novel rare earth tungstosilicic polyoxometalate containing 5-fluorouracil, K26 （C4 H4 FN2 O2）8 Pr （SiWn （h9）4 · 10H2O （FPSW） and K26 （C4 H4FN2O2 ）sSm（SiW11 O39 ）4 · 9H2O （FSSW）, were synthesized and their structure were characterized by using elemental analysis, FTIR spectra, X-ray powder diffraction and TG. The antitumor activity tests of the compounds FPSW and FSSW were carried out by the methyl thiazolyl tetrazolium method in hepatocellular carcinoma cell HepG-2. The results showed that FPSW and FSSW could inhibit the HepG-2 cells in vitro significantly. The EC50 of FPSW and FSSW is 1.94 × 10^-5 and 1.32 × 10^-5 mol · L^-1 respectively. The therapeutic index of FPSW and FSSW is 0. 76 and 1.58 respectively.
出处
《光谱学与光谱分析》
SCIE
EI
CAS
CSCD
北大核心
2012年第12期3309-3314,共6页
Spectroscopy and Spectral Analysis
基金
Project supported by Institution of Chemical Materials,China Academy of Engineering Physics
