摘要
目的:观察益肺解毒方对老年晚期非小细胞肺癌患者的生存质量的影响。方法:将63例老年晚期非小细胞肺癌患者随机分为中医组、化疗组、中西医结合组,中医组治以益肺解毒方,化疗组治以第三代细胞毒药物单药(吉西他滨或长春瑞滨或多西他赛)化疗。治疗时间为2个周期,以ECOG行为状态评分和EORTCQLQC-30量表为工具评价益肺解毒方对老年晚期非小细胞肺癌患者的生存质量的影响。中西组治化疗的同时加用中药。结果:中医组治疗后躯体功能、角色功能、情绪功能、疲倦、疼痛、呼吸困难、食欲丧失、大便异常等指标计分下降,与治疗前比较具有统计学差异(P<0.05或P<0.01);总健康状况计分提高,具有显著地统计学差异(P<0.05);行为状态评分有效率为85.71%;化疗组治疗后躯体功能、角色功能、情绪功能、认知功能、社会功能各维度以及疲倦、恶心呕吐、食欲丧失、大便异常、经济负担等状况的计分均较治疗前上升(P<0.05或P<0.01),行为状态评分有效率为65.00%。中西医组治疗后情绪功能明显下降(P<0.01),疲倦、恶心呕吐、经济负担的计分明显上升(P>0.05).且情绪功能积分下降与化疗组比较有显著差异(P<0.01)。化疗组组、中西医组治疗后恶心呕吐分均提高,治疗前后具有显著统计学差异(P<0.01),两组间比较无统计学差异(P>0.05)。化疗组与中医组比较在社会功能、疲倦、恶心呕吐、大便异常存在统计学差异(P<0.05或P<0.01)。结论:益肺解毒方能改善老年晚期非小细胞肺癌患者的生存质量。
Objective:To observe the effect of Yifei Jiedu Formula on quality of life of elderly patients with advanced non-small cell lung cancer.Methods:Sixty-three elderly patients with advanced non-small cell lung cancer were randomly divided into traditional Chinese medicine group,chemotherapy group,integrative medicine group.Traditional Chinese medicine group was treated with Yifei Jiedu Formula,chemotherapy group with a single third-generation cytotoxic drug(gemcitabine or Changchun vinorelbine or docetaxel) chemotherapy,integrative medicine group with chemotherapy plus Chinese medicine.Treatment time was 2 cycles,with ECOG performance status and EORTCQLQC-30 scale as a tool to evaluate the effect on quality of life of elderly patients with advanced non-small cell lung cancer.Results:After treatment,Chinese medicine physical function,role function,emotional function,fatigue,pain,difficulty breathing,loss of appetite,abnormal stools and other indicators were declined,compared with those before treatment there was a statistically significant difference(P〈0.05 or P〈0.01);total health points were increased,with a statistically significant difference(P〈0.05);performance status score effective rate was 85.71%.In chemotherapy group:physical function,role function,emotional function,cognitive function,social function of dimensions,as well as fatigue,nausea,vomiting,loss of appetite,abnormal stools,economic and other conditions of the scoring burden were increased(P〈0.05 or P〈0.01),performance status score rate was 65.00%.In integrative medicine group after treatment,emotional function was decreased significantly(P〈0.01),fatigue,nausea,vomiting and economic burden score were significantly increased(P〈0.05).And emotional function score decreased with the chemotherapy group were significantly different(P〈0.01).In chemotherapy group and integrative medicine group after treatment,nausea and vomiting scores were improved after treatment with a statistically significant difference(P〈0.01),but there was no significant difference between the two groups(P〈0.05).Chemotherapy group and Chinese medicine group had significant differences in group social functions,fatigue,nausea,vomiting and abnormal stools(P〈0.05 or P〈0.01).Conclusion:Yifei Jiedu Formula can improve quality of life of elderly patients with advanced non-small cell lung cancer patients.
出处
《辽宁中医杂志》
CAS
2012年第11期2176-2178,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
黑龙江省卫生厅课题(2011-275)
关键词
老年
肺癌
益肺解毒方
生存质量
elderly
lung cancer
Yifei Jiedu Formula
quality of life