补肾养肝熄风方药协同美多巴治疗帕金森病疗效观察

Clinical Observation on Effect of Bushen Yanggan Xifeng Recipe Combined with Madopar on Treating Parkinson's Disease

目的:观察自拟补肾养肝熄风方药配合美多巴治疗帕金森病(PD)的临床疗效。方法:83例PD患者采用随机对照方法分为两组。治疗组(40例)美多巴片加服补肾养肝熄风方剂;对照组(43例)仅服美多巴片,疗程均为12周,观察两组治疗前后帕金森病改良的统一评分量表(UPDRS)评分、临床疗效、改良Hoehn-Yahr(H-Y)分级情况、美多巴日使用量及不良反应。结果:治疗组的UPDRS评分、临床疗效明显优于对照组(P<0.05),两组的H-Y分级和美多巴使用量无显著性差异(P>0.05),但治疗组美多巴用量略有减少。结论:补肾养肝熄风方药协同美多巴治疗可以改善PD患者症状,提高生活质量。

Objective：To observe the curative effect of Self-designed Bushen Yanggan Xifeng Recipe combined with Madopar on treating Parkinson＇s disease（PD）.Methods：Eighty-three patients were randomly assigned to the treated group and the control group.The patients in control group（43 cases）were treated with Madopar,and the treated group（40 cases）was administered with Bushen Yanggan Xifeng Recipe additionally.The duration of treatment was 12 weeks.The unified Parkinson disease rating scale（UPDRS）,the clinical efficacy,HY grade assessment,Madopar dosage and adverse reactions were observed before and after treatment.Results：The UPDRS score and the clinical efficacy of the treated group were obviously better than those of the control group（P0.05）.The HY grade assessment and the Madopar dosage had no significant difference（P0.05）.However,Madopar dosage in the treatment group decreased slightly after treatment.Conclusion：The treatment of Bushen Yanggan Xifeng Recipe combined with Madopar can improve symptoms and life quality of PD patients.