不同通络中药对糖尿病大鼠神经传导速度的影响

Effect of Different Smoothing Collaterals Chinese Medicines on the Sciatic Nerve Conduction Velocity

目的:观察不同通络中药对糖尿病周围神经病变(DPN)大鼠传导速度的影响。方法:187只DPN大鼠,随机分为正常对照组、模型组、辛味通络组、藤类通络组、虫类通络组。分别于治疗后2周、4周、8周测定大鼠坐骨神经传导速度。结果:与正常对照组相比,模型组大鼠在造模后2周、4周、8周神经传导速度明显减慢,而且呈下降趋势(P<0.01)。各治疗组均能提高神经传导速度,与同期模型组比较均有显著性差异(P<0.01),同期各治疗组之间比较无显著性差异(P>0.05)。结论:不同通络中药随着疗程延长均具有延缓神经病变进程的作用。

Objective：To observe the effect of different smoothing collaterals Chinese medicines on the sciatic nerve conduction velocity.Methods：187 rats were randomly divided into five groups,including normal-control group,model-control group,Xingwei Tongluo group,Tenglei Tong luo group,Chonglei Tongluo group,the speed of conduction in sciatic nerve was detected in 2th,4th,8th week.Results：Compared with the normal group,the sciatic nerve conduction velocity of the model group was significantly slow on the 2th,4th,8th week after（P〈0.01）.The different smoothing collaterals Chinese medicine groups could accelerate the nerve conduction velocity.And at the same time there was also a significant difference between the different smoothing collaterals Chinese medicines groups and model group（P〈0.01）.Conclusion：The different smoothing collaterals Chinese medicine can postpone the proceed of neuropathy.