富勒烯及其衍生物在生物方面的应用

Application of Fullerene and its Derivatives in Biology

介绍了富勒烯及其衍生物对人体免疫缺陷病毒酶 (HIVp- 1)的抑制、DNA的裂解、消除自由基和对生物膜的双重作用等方面的应用 。

Fullerene (C 60 )has sttracted increasing attention since it was discovered in 1985. It has been xpected that C 60 has a biological action caused by its unique shape and characteristic physicochemical properties ,such as in a facial redox reaction and photosensitization .However,biological studies have been hindered because of the hydrophobic nature of fullerene. In an attempt to overcome problems associated with their insolubility in aqueous solution,the scope of application of fullerene and its derivatives in biology has been broaden. The article introduced application of fullerene and its water soluble derivatives in biology ,such as inhibition of HIV 1 protease ,cleavage of DNA,free radical remover or influence on cellular membranes ,and reviewed the possible interaction mechanism between fullerene and the matrix.