易修饰诱导基作用下的钯催化C-H键官能团化反应

Easily Modified Directing Groups for the Palladium-Catalyzed C—H Functionalization

基于Pd催化的C—H键官能团化反应是目前有机合成方法学的一个研究热点,诱导基对反应的区域选择性起着重要作用.综述了近年来关于易合成、易修饰的诱导基作用下的C—H键功能化反应的研究进展及其应用,介绍了各诱导基的作用、优势及其局限性,提出了今后的研究重点与发展趋势.

Palladium-catalyzed C--H functionalization is one of the hot topics in the field of organic synthesis methodology. Directing groups play an important role in the regioselectivity of C--H activation. Herein, this review presents the recent progress on the removable and transformable directing groups for the palladium-catalyzed C--H bonds activation and their applications in the synthesis of complicate molecules. Moreover, the research trend of this area is also prospected.