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抗体多样性遗传机制发现者——利根川进 被引量：1

Discoverer of genetic principle for antibody diversity——Susumu Tonegawa
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摘要 利根川进是一位日本分子生物学家,由于发现了抗体多样性产生的遗传机制而获得1987年诺贝尔生理学或医学奖;利根川进还由于研究了学习和记忆的分子与细胞机制而闻名。文章介绍了利根川进的生平和科研情况。 Susumu Tonegawa is a Japanese molecular biologist who won the Nobel Prize for Physiology or Medicine in 1987 for his discovery of ＂the genetic principle for generation of antibody diversity＂. Susumu Tonegawa is also famous for his important contributions on neuroscience, who explored the molecular and cellular mechanisms underlying learning and memory. In this article, the life and research on Susumu Tonegawa was introduced.
作者 郭晓强
机构地区 解放军白求恩军医学院生化教研室
出处 《遗传》 CAS CSCD 北大核心 2012年第11期1501-1504,共4页 Hereditas（Beijing)
关键词 利根川进 抗体多样性 遗传机制 诺贝尔生理学或医学奖 Susumu Tonegawa antibody diversity genetic principle Nobel Prize for Physiology or Medicine
分类号 Q3 [生物学—遗传学] K833.13 [历史地理—历史学]
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参考文献14

  • 1Shampo MA, Kyle RA, Steensma DE Susumu Tonegawa-Japan's first Nobel laureate in physiology or medicine. Mayo Clin Proc, 2011, 86(2): e14.
  • 2Tonegawa S, Hayashi M. Genetic transcription directed by the b2 region of lambda bacteriophage. Proc Natl Acad Sci USA, 1968, 61(4): 1320-1327.
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  • 8Tonegawa S. Somatic generation of antibody diversity. Nature, 1983, 302(5909): 575-581.
  • 9郭晓强.自动测序仪的发明者——记科学家胡德[J].生物学通报,2005,40(6):58-59. 被引量：3
  • 10Hayday AC, Diamond D J, Tanigawa G, Heilig JS, Folsom V, Saito H, Tonegawa S. Unusual organization and diversity of T-cell receptor a-chain genes. Nature, 1985, 316(6031): 828-832.

二级参考文献3

  • 1Hunkapiller M.W.Hood L.E.New Protein Sequenator with Increased Sensitivity.Science,1980,207(4430):523-525.
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  • 3郭晓强.拉斯克基础医学奖简介(2)[J].生物学通报,2003,38(10):59-60. 被引量：6

共引文献2

同被引文献15

  • 1NELSON A L, DHIMOLEA E, REICHERT J M. Development trends for human monoclonal antibody therapeutics [J]. Nat Rev Drug Discov, 2010, 9: 767-774.
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  • 5PRESTA L G. Engineering of therapeutic antibodies to minimize immunogenicity and optimize function [J]. Adv Drug Deliv Rev, 2006, 58: 640-656.
  • 6JONES P T, DEAR P H, FOOTE J, et al. Replacing the complementarity-determining regions in a human antibody with those from a mouse [J]. Nature, 1986, 321 : 522-525.
  • 7VAUGHAN T J, OSBOURN J K, TEMPEST P R. Human antibodies by design [J]. Nat Biotechnol, 1998, 16: 535-539.
  • 8WINTER G, GRIFFITHS A D, HAWKINS R E, et al. Making antibodies by phage display technology [J]. Annu Rev Immunol, 1994, 12: 433-455.
  • 9BRADBURY A R, MARKS J D. Antibodies from phage antibody libraries [J]. J Immunol Methods, 2004, 290: 29-49.
  • 10LONBERG N. Fully human antibodies from transgenic mouse and phage display platforms [J]. Curt Opin Immunol, 2008, 20: 450-459.

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2012年 第11期

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