1999—2011年河南省碘缺乏病实验室外质控考核结果分析

External quality control of iodine deficiency disorders laboratory in Henan province from 1999 to 2011

目的分析河南省各级碘缺乏病（IDD）实验室外质控考核结果及网络运行情况，为IDD的监测和防治提供可靠的实验室质量保障。方法对1999—2011年河南省各级IDD实验室参加国家IDD参照实验室（NRL）的外质控考核结果进行统计学分析。结果13年来，省级实验室尿碘和盐碘的考核结果均为合格。地市级实验室尿碘反馈率均为100．0％，通过参加外质控考核工作，实验室检测能力有了明显提高并趋于稳定，1999—2001年，尿碘考核合格率分别为22．2％（4／18）、72．2％（13／18）、94．4％（17／18），除2003年尿碘合格率为94．4％（17／18）外，2002—2011年，尿碘合格率稳定在100．0％（18／18）。从2000年起，地市级实验室开始参加盐碘外质控考核，2000—2011年碘盐反馈率均为100．O％（18／18）。除2003年，合格率为88．9％（16／18）以外，2000—2011年各年度合格率均为100．0％（18／18）。2003年和2004年，郑州市分别有6、7个县级实验室参加尿碘外质控考核，全部合格。参加盐碘质控网络的县级实验室数量由1999年的29个增加至2011年的148个，除2003、2006、2007年反馈率分别为94．4％（68／72）、96．7％（58／60）、92．3％（144／156）以外，其余各年份反馈率稳定在100．0％。1999年，盐碘考核合格率在69．0％（20／29），之后合格率明显提高，除2001、2007年合格率分别为86．7％（26／30）、84．6％（132／156）以外，其余各年份稳定在90．0％以上，其中2000年和2009年，合格率均达100．0％。结论各级实验室尿碘与盐碘外质控测定准确性与IDD实验室条件和人员技术力量密切相关。

Objective To analyze the examination results of external quality assessment（EQA） at all levels of iodine deficiency disorders （IDD） laboratories in Henan province and the network operation to further standardize and improve the laboratory, and to provide reliable laboratory quality assurance for surveillance and control of IDD. Methods The examination resuhs of EQA at all levels of IDD laboratories in Henan province were statistically analyzed in accordance with the National Reference Laboratory（NRL） of IDD（1999 - 2011）. Results The survey results showed that the provincial level laboratory was all qualified in testing urinary iodine and salt iodine in the past 13 years. In prefectural level, the laboratory response rates were 100.0%, and through participation in EQA, laboratory capacity had been significantly increased and stabilized. From 1999 to 2001, the passing rate of check up of urinary iodine was 22.2%（4/18）,72.2%（13/18）,94.4%（17/18）, respectively, and the rate was stable at 100.0% （18/18） from 2002 to 2011 except 94.4% （17/18） in 2003. Since 2000, the prefectural level laboratory began to take part in the salt iodine EQA, and the laboratory response rate was 100.0%（18/18） from 2000 to 2011. Except 88.9% （16/18） in 2003,the passing rate of check up of urinary iodine was 100.0% （18/18）from 2000 to 2011. In 2003 and 2004, 6 to 7 county-level laboratories participated in the EQA of urinary iodine in Zhengzhou city, respectively, and all qualified. The number of county-level laboratories that participated in the salt iodine quality control network increased from 29 in 1999 to 148 in 2011. Response rate was 94.4%（68/72）, 96.7%（58/60） and 92.3% （144/156）in 2003, 2006 and 2007, respectively, and the rate remained stable at 100.0% in the remaining 10 years. In 1999, the passing rate was 69.0% （20/29）, then increased significantly, except 86.7% （26/30） in 2001 and 84.6%（132/156） in 2007, the rates were all above 90.0% in other years, especially in 2000 and 2009, the passing rates were both 100.0%. Conclusions The accuracy of test results of external quality controls and the normal operation of the network at all levels of laboratories is closely related to the IDD laboratory conditions and detection techniques.