摘要
目的通过检测β1-肾上腺素能受体自身抗体,以探讨β受体阻滞剂治疗顽固性心衰患者对β1-肾上腺素能受体自身抗体、抗体滴度及心功能的影响。方法随机选取120例心力衰竭NYHA分级Ⅱ-Ⅲ级患者,分为两组,A组:比索洛尔首剂1.25mg qd,每两周逐渐加量,直至10mg qd;B组:比索洛尔首剂1.25mg qd,4周后逐渐加至5mgqd。比较两组β1-肾上腺素能受体自身抗体及心功能各项指标的变化。结果 A组β1-肾上腺素能受体自身抗体及滴度较B组明显降低,心功能各项指标有改善的趋势。结论通过检测β1-肾上腺素能受体自身抗体,发现比索洛尔剂量的增加使β1-肾上腺素能受体自身抗体阳性率及抗体滴度明显降低,并改善了顽固性心力衰竭患者的心功能。
Objective Influences of β1-AR autoantibodies on relevant the treatment Decompensated heart failure by bisoprolol.Methods The patients（n=120）with Decompensated heart failure were chosen and randomly divided into the group A and the group B.Group A：bisoprolol from 1.25mg qd,and added after two weeks until 10mg qd;Group B：bisoprolol from 1.25mg qd,and added after four weeks until 5mg qd.β1-AR autoantibodies and heart functionwere compared.Results The group A after bisoprolol treatment β1-AR autoantibodies positive rate and average titer was depressed than the group B,The heart function was better than before.Conclusion bisoprolol can reduce β1-AR autoantibodies positive rate and average titer level by higher titer and increase heart function by survey β1-AR autoantibodies positive rate and average titer level.
出处
《中国实验诊断学》
2012年第11期2044-2046,共3页
Chinese Journal of Laboratory Diagnosis
