上皮性卵巢癌中P53蛋白的表达与化疗敏感相关性

Correlation of P53 protein expression in epithelial ovarian and chemotherapy sensitivity

目的探讨P53蛋白表达不同的上皮性卵巢癌患者对一线标准化疗方案敏感性的预测作用。方法通过回顾性分析收集经规范的卵巢癌分期手术、满意或较满意的肿瘤细胞减灭术的上皮性卵巢癌患者共230例,根据术后卵巢癌组织的免疫组化分析,按P53蛋白的表达水平分为P53表达阳性组142例和P53表达阴性组88例。术后予规范的以铂类为基础的一线化疗,分析P53蛋白的不同表达与化疗前后肿瘤标记物糖类抗原125(CA125)值的下降率之间的相关性,并比较研究组与对照组患者化疗疗效的差异。结果 Spearman相关分析发现P53蛋白的表达与化疗后CA125值下降率之间存在负相关(r=-0.153,P=0.021),2组不同P53蛋白表达的患者近期疗效有显著差异(P=0.041)。结论上皮性卵巢癌中P53蛋白的不同表达与患者的化疗敏感性相关,肿瘤组织中P53表达阴性的患者对术后紫杉醇联合卡铂的标准一线化疗方案可能更为敏感。

AIM To compare the different expression of P53 and to analyze the correlation between the efficacy of chemotherapy and the expression levels of P53. METHODS A total of 230 patients with epithelial ovarian cancer （EOC） , who underwent optimal cytoreductive surgery and received regular postoperative chemotherapy in Obstetrics ＆ Gynecology Hospital of Fudan University, were recruited in this study. Among the 230 patients, 142 patients were in P53 positive group, 88 patients were in P53 negative group. Retrospective clinical characteristics were reviewed respectively and compared. Statistical analysis was performed to study the relationship between P53 protein expression and the efficacy of chemotherapy, and to compare the efficacy of chemotherapy between the different expressions of immunohistochemical protein. RESULTS Spearman correla- tion analysis revealed significant negative correlation between P53 protein expression and chemotherapy sensitivity （P 〈 0.05）. Compared with patients in P53 positive group, patients in P53 negative group were more likely to have the higher extent of the decrease of serum CA125 level after optimal cytoreductive surgery and chemotherapy （P 〈 0.05）. CONCLUSION P53 protein expression is related tO the chemotherapy sensitivity of the patients with EOC. Patients whose P53 negative expression in tumor tissue may be more sensitive in negative patients to the standard forefront chemotherapy scheme of paclitaxel combined with carboplatin on post operation.