组合型人工肾在透析患者肾性贫血中的疗效观察

Combination type artificial kidney in hemodialysis patients with renal anemia in curative effect observation

目的:探讨组合型人工肾(HP/HD)在治疗血液透析患者肾性贫血中的临床疗效。方法:将维持性血液透析1年以上的患者60例随机分为普通透析HD组30例,组合型人工肾(HP/HD)组30例。HD组采取维持性HD治疗,每周透析3次,每次透析4h,组合型人工肾(HP/HD)组每周行1次HP/HD,HD治疗2次,时间均4 h。所有患者均在上机治疗前后及6个月后空腹采血,观察两组各项指标的变化。结果:治疗后组合型人工肾(HP/HD)组中大分子量毒素β2-MG、iPTH与HD组比较明显下降,与HD组比较Hb明显升高,有统计学差异(P<0.05)。结论:组合型人工肾(HP/HD)增加了对中大分子量毒素的清除,治疗肾性贫血效果优于普通HD。

Objective Explore the clinical efficacy of the combination of artificial kidney（HP/HD）in the treatment of hemodialysis patients with renal anemia. Method In maintenance hemodialysis patients with more than one year 60 cases were randomly divided into normal HD group of 30 patients,the combination of an artificial kidney （HP/HD）group of 30 patients.The HD group maintenance HD treatment and dialysis three times a week,each dialysis 4h,a combination artificial kidney（HP/HD）group weekly for line 1 the HP/HD,HD treatment times,at all times for 4 h.All patients were on the machine before and after treatment and six months after the fasting blood collection,and to observe the changes of the two sets of indicators. Results After treatment combination of artificial kidney（HP/HD） high molecular weight toxinsβ2-MG group of iPTH HD group decreased significantly higher with the HD group Hb,significant differences （P〈0.05）. Conclusions The combination of artificial kidney （HP/HD）increased clearance of the Zhongshan University molecular weight toxins,the treatment of renal anemia effect is better than ordinary HD.