超声实时组织弹性成像技术在甲状腺弥漫性病变中的应用

Application of ultrasound real-time elastography in diagnosis of thyroid diffuse disease

目的探讨超声实时组织弹性成像(RTE)技术在甲状腺弥漫性病变中的应用价值。方法甲状腺功能亢进组(甲亢组)27例,桥本甲状腺炎组(桥本组)22例,健康体检志愿者22例为对照组,超声测量甲状腺左、右叶前后径、峡部厚度和甲状腺上动脉收缩期峰值流速;RTE测量11个弹性参数,多元线性回归方程计算弹性系数(EI)。结果甲亢组、桥本组甲状腺左、右叶前后径、峡部厚度均大于对照组,甲亢组左、右侧甲状腺上动脉收缩期峰值流速高于对照组及桥本组;甲亢组、对照组、桥本组EI分别为1.40±0.44、1.85±0.26、2.56±0.50,依次增大,差异均有统计学意义(P<0.05)。EI与甲状腺上动脉收缩期峰值流速无相关性。结论 RTE技术能够通过测量甲状腺EI来反映甲状腺弥漫性病变组织硬度,可以间接推断甲状腺的病理变化进程。

Objective To explore application value of ultrasound real-time tissue elastography in the diagnosis of thyroid diffuse disease. Methods Twenty-seven patients with hyperthyroidism,22 patients with hashimoto＇s thyroiditis and 22 healthy volunteers were enrolled. Ultrasonography was applied to measure width and thickness of each lobe ,thickness of isthmus, and peak systolic velocity of thyroid artery. Eleven elastic parameters were measured by real-time tissue elastography. Multiple linear regression equation was used to calculate coefficient of elastieity（EI）. Results Width and thickness of each lobe and thickness of isthmus of hyperthyroidism group and hashimoto group were greater than those of control group. The peak systolic velocity of thyroid artery in hyperthyroidism group were higher than those in control group and hashimoto group. El of hyperthyroidism group was 1.40 ±0.44. EI of control group were 1.85±0.26. El of hashimoto group was 2.56±0.50. There were significant differences in EI among all groups （P 〈 0.05）. No correlation was found between EI and peak systolic velocity. Conclusion RTE technology can reflect tissue hardness of thyroid diffuse disease and infer pathological change of thyroid indirectly.