系统性红斑狼疮患者血管内皮功能的超声评价

Value of ultrasonography in evaluation of artery endothelial function in patients with systemic lupus erythematosus

目的探讨超声评价系统性红斑狼疮(SLE)患者血管内皮依赖性舒张功能的价值。方法 SLE患者94例(SLE组),体检健康正常者40例为对照组,超声测量两组静息状态下和反应性充血后的肱动脉内径,计算血流介导的肱动脉内皮依赖性舒张(FMD)。将患者按照病程(≥3年和<3年)、SLEDAI评分(≥10分和<10分)、年龄(>37岁和≤37岁)分别分组,比较各组FMD差异。结果 SLE组、≥10分组、<3年组、≤37岁组及>37岁组的FMD均低于对照组(P<0.05)。SLEDAI评分与FMD无明确相关性。SLE组和对照组的FMD数据重叠范围大,未能确定其正常值范围。结论 SLE患者FMD降低,提示肱动脉内皮功能减低;但FMD因为技术局限及缺乏正常标准,目前尚不能用于判断患者个体内皮功能。

Objective To explore the value of ultrasonography in the evaluation of artery endothelial function in patients with systemic lupus erythematosus （SLE）. Methods Ninety-four patients with SLE and 40 healthy volunteers were enrolled. Brachial artery diameter was measured by uhrasonography at rest state and after reactive hyperaemia, and flow mediated dilatation （FMD）was calculated. Patients with SLE were divided groups according to course of disease, score and age. The differences of FMD among all groups were compared. Results FMD of SLE group （≥ 10 scores, 〈3 years, ≤37 and 〉37 years） was lower than that of control group （P〈0.05）. No clear correlation was found between SLEDAI score and FMD. SLE group and control group share similar range of FMD. It was failed to determine relative normal range of FMD. Conclusion The endothelium dependent dilation function decreases in patients with SLE. Because of technical limitation and lack of normal standard, FMD can not be used to judge the endothelial function of individual patient.