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支气管哮喘发病机制的基因研究进展 被引量：4

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摘要 支气管哮喘（简称哮喘）是一种慢性气道炎症性疾病，哮喘的发生与发展主要由环境因素和遗传因素共同作用所致，多种基因共同参与，基因与基因间、基因与环境因素间相互作用形成的多因素多基因模式，是复杂性状多基因遗传病，遗传率为36％-79％，其遗传不遵循Mendel定律。临床上哮喘患者常有明显的家族史，印证了遗传机制在哮喘发病中的重要作用。近十年来全球各地的实验室利用多种方法搜寻哮喘相关表型的易感基因或致病基因，
作者 韦旋 邓静敏
机构地区 广西医科大学第一附属医院呼吸内科
出处 《中华结核和呼吸杂志》 CAS CSCD 北大核心 2012年第11期849-852,共4页 Chinese Journal of Tuberculosis and Respiratory Diseases
关键词 多基因遗传病 支气管哮喘 发病机制 慢性气道炎症性疾病 遗传因素 环境因素 相互作用 哮喘患者
分类号 R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献26

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二级参考文献40

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  • 3邱玉明,罗雅玲,赖文岩,邱士军,吴月仙.ADAM33基因Met764Thr位点多态性与支气管哮喘发病及患者肺功能的相关性[J].中华结核和呼吸杂志,2007,30(7):518-521. 被引量：22
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共引文献39

同被引文献57

  • 1方桂桔,焦维克,薛青,李树奇.支气管哮喘未控制患者生活质量与肺功能及情绪因素相关性分析[J].中华哮喘杂志（电子版）,2013,7(1):32-34. 被引量：17
  • 2俞峰,周林福.氨茶碱和多索茶碱治疗支气管哮喘的临床疗效比较[J].中国生化药物杂志,2014,34(6):8-10. 被引量：87
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引证文献4

二级引证文献13

中华结核和呼吸杂志
2012年 第11期

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