HSP27在青老年大肠癌中的表达差异

Clinical significance of HSP27 expression in the young and aged with colorectal cancer

目的探讨青老年组大肠癌中不同临床病理特征及HSP27表达水平的查因。方法应用免疫组化SP法测定175例青老年大肠癌中HSP27的表达,青年患者20例,老年患者155例,比较HSP27在两组人群中的表达差异。统计分析青老年组不同临床病理特征。结果青老年组大肠癌均好发于直肠,直肠占66.9%(117/175),两组部位构成比差异无显著性(P>0.05)。TNM分期中0、I期占17.7%(31/175),青年组TNM分期(0+Ⅰ/Ⅱ+Ⅲ+Ⅳ)与老年组比较,差异无显著性(P>0.05)。青年组低分化癌比例高于老年组,差异有显著性(P<0.05)。青老年组5年生存率差异无显著性(P>0.05)。青老年组HSP27阳性表达比差异无显著性(P>0.05)。结论青年大肠癌恶性程度较高。若能早期发现及时手术,预后尚可。HSP27在青老年大肠癌中差异无统计学意义。

Objective To investigate HSP27 expression in the young and aged with colorectal cancer and the correlations with clinic pathological parameters in those cancer. Methods HSP27 monoclonal antibody was detected by immunohistochemical SP method in 175 cases of colorectal cancer. 20 cases were young patients and 155 cases were the aged. Results There was no significance of ratio of colon cancer between the young and aged （P 〉 0. 05）. The total ratio of colon cancer was 66.9% （117/175） in colorectal cancer. There was also no significance of TNM stage, 5-year survival ratio and positive ratio of HSP27 expression between the young and aged （P 〉 0.05）. But there was a signifi- cant correlation of tumor differentiation between the young and aged （P 〈 0.05）. Conclusion Young patients with colorectal cancer have poor prognostic result only if they were detected in time. There is no significance of HSP27 expression between the young and aged with colorectal cancer