MIC-1和uPA蛋白在皮肤鳞状细胞癌组织中的表达及与组织学分级和发病部位的关系

Expression of MIC-1 and uPA Protein in Cutaneous Squamous Cell Carcinoma and Their Correlation with Histological Grade,Location

目的 探讨MIC-1和uPA蛋白在皮肤鳞状细胞癌中的表达及与组织学分级和发病部位的关系。方法 应用免疫组化SP法检测42例皮肤鳞状细胞癌组织及42例正常对照皮肤中MIC-1及uPA蛋白的表达,并分析其与组织学分级及发病部位的关系。结果 皮肤鳞状细胞癌组织中MIC-1(66.67%)及uPA蛋白(78.57%)阳性表达率均显著高于正常对照皮肤组织中的阳性表达率(16.67%和28.57%),差异均有统计学意义(P均<0.05);皮肤鳞状细胞癌组织中MIC-1及uPA蛋白阳性表达率均与鳞状细胞癌病理组织学分级密切相关(P均<0.05);MIC-1与uPA蛋白的表达呈正相关(P<0.05)。结论 皮肤鳞状细胞癌组织中MIC-1和uPA蛋白的表达均显著升高,其高表达可能与皮肤鳞状细胞癌发生和发展有关。

Objective To explore the expression of MIC-1 ,uPA protein in cutaneous squamous cell carcinoma（CSCC） and analyse their correlation ship with histological grade, location. Methods SP immunohistochemieal method was used to detect the expression of MIC-1, uPA protein in 42 cases of CSCC tissue and 42 cases of normal skin tissue. Then analyze their correlation with histological grade and location. Results The positive expression rates of MIC-1 （66.67%） and uPA（78.57% ） protein in CSCC were obviously higher than those in normal skin （positive expression ratios： 16.67% and 28.57% ） , and there were significant differences be- tween 2 groups （ both P 〈 0.05 ）. The positive expression rate of MIC-1 and uPA were both closely correlated with the histological grade in CSCC （ both P 〈 0.05 ） and there was positive correlation between MIC-1 and uPA protein expression（ P 〈 0.05 ）. Conclusion The expression of MIC-1 and uPA protein increased in CSCC tissue,which suggests their over-expression may be related to oneogenesis and development of CSCC.