胺碘酮联合心理干预治疗非瓣膜病心房纤颤伴抑郁症的临床研究

Clinical research of Amiodaron combined the psychological in treatment of non-valvular atrial fibrillation with depression

目的研究胺碘酮联合心理干预治疗非瓣膜病房颤伴抑郁症的临床疗效。方法选择了91例非瓣膜病房颤伴抑郁症患者,应用抑郁自律量表(SDS)及汉密顿抑郁自律量表(HRSD)评价。其中有50例并发有抑郁症状,按随机数学数表分为心理干预组和对照组,每组均为25例,对照组按常规治疗2周负荷量为7g,维持量为0.2g,干预组在常规治疗基础上给予心理干预,2组均为治疗组,用上述方法进行治疗后评故给予动态心电图监测。结果治疗2个月后,干预组较对照组抑郁症明显改善,组间区别P<0.05,动态心电图证实,阵发性房颤不发作,持续性房颤转为并维持窦性心律或变为偶有发作的阵发性房颤。结论胺碘酮联合心理干预治疗非瓣膜病房颤伴抑郁症,毒性小,疗效高,安全性大。

Objective To research the clinical effective of the psychological combined Amiodaron in treatment of non-valvular atrial Fibrillation with the depression.Methods Choose the patients whom with the non-valvular atrial fibrillation with depression used the self-Discipline Scale（SDS） and Hamilton depression self-discipline scale（HRSD） for evaluation.50 cases have concurrent depressive symptoms,according random mathematical number table were divided into psychological intervention group and control group were 25 cases,the control group two weeks of conventional treatment load 7g,maintenance dose was 0.2g,the intervention group was given conventional treatment based on psychological intervention,both are treatment groups,after treatment using the above method then given the evaluation by Holter monitor.Results After 2 months of treatment,the intervention group compared with the control group significantly improved depression,P0.05.The dynamic electrocardiogram confirmed,the paroxysmal atrial fibrillation do not attack,persistent AF converted to sinus rhythm and maintenance or becomes occasionalepisodes of paroxysmal atrial fibrillation.Conclusions Psychological intervention combined amiodarone treatment of non-valvular atrial fibrillation with depression,low toxicity,high efficacy and safety.