牛磺酸保护体外冲击波碎石术致肾脏损伤的临床研究

Protective effects of taurine on renal injury induced by extracorporeal shock wave lithotripsy

目的探讨牛磺酸对体外冲击波碎石术(ESWL)致肾脏损伤的保护作用及机制。方法将60例肾结石患者按半随机法分成牛磺酸组和对照组,每组30例。于ESWL前1d开始分别口服牛磺酸粉和安慰剂2g/次,3次/d,共7d,术前及术后1d、3d、7d测定患者尿微量白蛋白(ALB)、β2-微球蛋白(β2-MG)、内皮素-1(ET-1)及丙二醛(MDA)的变化。结果冲击前两组尿ALB、β2-MG、ET-1、MDA比较差异无统计学意义(P>0.05)。对照组冲击后1d、3d尿ALB、β2-MG、ET-1、MDA均显著升高,与牛磺酸组相比,差异均有统计学意义(P<0.001)。结论牛磺酸对ESWL致肾损伤有保护作用,其保护机制可能与其抗氧化作用和抑制ET-1生成有关。

Objective To evaluate the protective effect of tanrine on renal injury induced by extracorporeal shock wave lithotripsy（ESWL）. Methods Sixty patients with kidney stones were divided into the taurine group （ n = 30） and the control group （n = 30） at random. The two groups were respectively given 6g taurine and 6g placebo each day from the day before the ESWL to 6th day after the ESWL. The urinary samples were taken on the preopera- tive day and 1 th, 3 th,7 th day after the ESWL for determination of albumin （ ALB ） , β2-microglobttIin （ β2 -MG ） , endothelin （ET-1） and malondialdehyde （MDA）. Results There were no significant difference between the two groups of urinary ALB, β2-MG, ET-1, MDA before the ESWL（ P 〉 0.05 ）. In the control group,the indexs were significantly elevated on the 1 th ,3th day after the ESWL compared with pre-treatment and the taurine group （P 〈 0. 001 ）. Conclusion Taurine is effective in the protection of kidney against injury induced by ESWL. The mechanism may be related with its antioxidation capability and inhibition of ET-1 generation in kidney.