糖尿病脂肪肝与胰岛素抵抗的相关性研究

The Associativity Study on Diabetic Fatty Liver and Insulin Resistance

目的:观察糖尿病脂肪肝与胰岛素抵抗的关系,以了解糖尿病脂肪肝与胰岛素抵抗的相关性,探讨改善胰岛素抵抗对于防治糖尿病脂肪肝的意义。方法:对60例糖尿病合并脂肪肝患者与108例糖尿病不合并脂肪肝患者血糖、糖基化血红蛋白、血脂、胰岛素、血液流变学、肝脏B超等指标进行观察测定,同时计算胰岛素敏感指数(IAI)、胰岛素抵抗指数(IR)、体重指数(BMI)并对以上数据进行分析比较。结果:糖尿病合并脂肪肝患者呈明显的高血糖、高血脂、高血黏、高胰岛素血症的"四高"倾向,而胰岛素敏感指数却明显下降、胰岛素抵抗指数明显升高,与对照组比较有显著性差异(P<0.01或0.05)。结论:糖尿病脂肪肝的发生与胰岛素抵抗关系密切,改善胰岛素抵抗对防治糖尿病脂肪肝具有重要意义。

Objective ：To investigate the relationship between insulin resistance and diabetic fatty liver to understand the associativity on diabetic fatty liver and insulin resistance as well as the significance of improving insulin resistance on prevention and treatment of diabetic fatty liver. Methods ：60 cases with diabetic fatty liver and 108 eases with diabetes but no fatty liver were chosen, and their blood sugar （BS）, glycosylated hemoglobin （GH）, blood -fat, insulin, haemorheology and type B ultrasound on liver were determined. At the same time insulin sensitivity index （ISI） ,insulin resistance index （IR） and body mass index （BMI） were calculated and analyzed. Results：The cases with diabetes combined with fatty liver showed ＂four high＂ tendency,which were high blood sugar, high blood fat, high blood viscosity, and hyperinsulinemia, but insulin sensitivity index （ISI） decreased, insulin resistance index increased markedly. There was significant difference between treatment group and control group （P 〈 0. 01 or P 〈 0. 05 ）. Conclusion ： Diabetic fatty liver are closely associated with insulin resistance. Improving insulin resistance has important significance in the prevention and treatment of diabetic fatty liver.