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hMSH2-118T>C基因多态性与宫颈癌易感的相关性研究

Association between the hMSH2-118T>C polymorphism and the risk for cervical cancer
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摘要 目的探讨hMSH2-118T>C基因多态性与广东汉族妇女宫颈癌易感的相关性。方法采用分子流行病学研究方法,收集113例经病理学确诊为宫颈癌的新发患者为病例组,280例年龄相匹配的健康体检者作为对照组;采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)分析技术,对hMSH2基因-118T>C多态位点进行分型,采用非条件逻辑回归分析统计该多态位点与宫颈癌易感的相关性。结果病例组与对照组间基因型频率分布差异无统计学意义(P=0.91);以TT基因型作为参照,TC、CC基因型均没有显著增加个体患宫颈癌的风险(OR分别为1.10和1.14,95%CI分别为0.69-1.77和0.34-3.82)。结论 hMSH2基因-118T>C多态性与广东汉族妇女宫颈癌易感性无关。 Objective To investigate the relationship between the hMSH2-118T 〉 C polymorphism and the susceptibility of cervical cancer in ethnic Han Cantonese population. Methods The genotypes of the hMSH2-118T 〉 C polymorphism were determined in 113 cervical cancer patients and 280 age-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Association between the polymorphism and the risk for cervical cancer was evaluated using unconditional logistic regres- sion analysis. Results No significant difference was observed in the frequency of hMSH2-11ST 〉 C between cases and controls(P = 0.91 ). Taking 'IT genotype as reference, no significantly increased risk for cervical cancer was observed for those carrying TC or CC genotypes(OR = 1.10,95 %CI0.69-1.77;OR = 1.14,95 %CI0.34-3.82,respectively) . Conclusion ThehMSH2-118T〉 C polymorphism is not associated with the susceptibility of cervical cancer in ethnic Han Cantonese population.
出处 《山西医科大学学报》 CAS 2012年第11期813-816,824,885,共6页 Journal of Shanxi Medical University
基金 广东省医学科研基金资助项目(2010068)
关键词 HMSH2 宫颈癌 单核苷酸多态性 遗传易感性 hMSH2 cervical cancer single nucleotide polymorphism genetic susceptibility
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参考文献26

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